Exogenous RvD1 treatment attenuated EAN

Slides:

Advertisements

Similar presentations

Journal of Surgical Research

Advertisements

Hesperidin ameliorates immunological outcome and reduces neuroinflammation in the mouse model of multiple sclerosis Dariush Haghmorad, Mohammad Bagher.

Volume 42, Issue 1, Pages (January 2005)

Volume 143, Issue 5, Pages (November 2012)

Effects of cytokines on P450 mRNA expression in human hepatocytes.

Fig. 3. Cytokines trigger proliferation and block differentiation of perivascular adipocytes. Cytokines trigger proliferation and block differentiation.

IL-6 Blockade Attenuates the Development of Murine Sclerodermatous Chronic Graft- Versus-Host Disease Doanh Le Huu, Takashi Matsushita, Guihua Jin, Yasuhito.

Z. Y. Yu, J. Geng, Z. Q. Li, Y. B. Sun, S. L. Wang, J. Masters, D. X

IN-1130, a novel transforming growth factor-β type I receptor kinase (ALK5) inhibitor, suppresses renal fibrosis in obstructive nephropathy J.-A. Moon,

A GPR40 Agonist GW9508 Suppresses CCL5, CCL17, and CXCL10 Induction in Keratinocytes and Attenuates Cutaneous Immune Inflammation Tomoko Fujita, Toshiyuki.

Exaggerated inflammatory environment decreases BMP-2/ACS-induced ectopic bone mass in a rat model: implications for clinical use of BMP-2 R.-L. Huang,

Inhibition of complement C5 reduces local and remote organ injury after intestinal ischemia/reperfusion in the rat Koichiro Wada, Michael C. Montalto,

Absence of donor Th17 leads to augmented Th1 differentiation and exacerbated acute graft-versus-host disease by Tangsheng Yi, Dongchang Zhao, Chia-Lei.

Fig. 5. Immunohistochemistry of the tumor microenvironment in GBM specimens before and after CART-EGFRvIII infusion. Immunohistochemistry of the tumor.

Figure S4 A C Vehicle control AC0010 (300mg/kg) Gefitinib (50mg/kg) D

Culture medium from TNF-α–stimulated mesenchymal stem cells attenuates allergic conjunctivitis through multiple antiallergic mechanisms Wenru Su, MD,

A novel NF-κB inhibitor, dehydroxymethylepoxyquinomicin, ameliorates inflammatory colonic injury in mice Tohru Funakoshi, Kenichiro Yamashita, Nobuki.

Influenza Virus-Induced Glucocorticoids Compromise Innate Host Defense against a Secondary Bacterial Infection Amanda M. Jamieson, Shuang Yu, Charles.

Volume 31, Issue 2, Pages (August 2009)

Figure 5 Cytokine release and stimulation of cells during alemtuzumab treatment Cytokine release and stimulation of cells during alemtuzumab treatment.

Targeting Effector Memory T Cells with the Small Molecule Kv1

Altered cytokine production by Klrk1−/− NOD CTL

Volume 25, Issue 8, Pages (August 2017)

Fig. 3 In situ vaccination with CpG and anti-OX40 is therapeutic in a spontaneous tumor model. In situ vaccination with CpG and anti-OX40 is therapeutic.

Effects of IL-1α on the composition of infiltrating proinflammatory cells in inflamed colons during DSS-induced colitis. Effects of IL-1α on the composition.

Fig. 4. Analysis of T cell responses according to treatment and in peptide-treated C-peptide responders and nonresponders. Analysis of T cell responses.

Histological changes in mouse colons after DSS treatment.

IL-33 treatment improves restorative macrophages (MΦ) but not function

Profiles of anti-inflammatory cytokines after endotoxin injection.

Fig. 4 TNF-α up-regulates Fas/Fap-1 expression to promote IL-1RA–sEV release in murine MSCs. TNF-α up-regulates Fas/Fap-1 expression to promote IL-1RA–sEV.

Blockade of NFκB activation and renal inflammation by ultrasound-mediated gene transfer of Smad7 in rat remnant kidney Yee-Yung Ng, Chun-Cheng Hou, Wansheng.

Pivotal Role of Dermal IL-17-Producing γδ T Cells in Skin Inflammation

CD137/NFATc1 Axis Activated NLRP3 Inflammasome in Vascular Smooth Muscle Cells (A) Western blot and quantitative results of NLRP3, pro-IL-1β, and mature.

Volume 18, Issue 4, Pages (April 2010)

Differential Expression of Cytokine mRNA in Skin Specimens from Patients with Erythema Migrans or Acrodermatitis Chronica Atrophicans Robert R. Müllegger,

Volume 15, Issue 3, Pages (April 2016)

Volume 43, Issue 6, Pages (December 2015)

Histological and mRNA analysis of the inflammatory cytokines in the vehicle‐ or etifoxine‐treated mice at onset of clinical symptoms.A–D.At day 10 p.i.,

Keratinocytes Inhibit Expression of Connective Tissue Growth Factor in Fibroblasts In Vitro by an Interleukin-1α-Dependent Mechanism Daniel Nowinski,

Effect of CIA and treatment with 3,4-dichloropropionaniline (DCPA) on production of key serum inflammatory factors. Effect of CIA and treatment with 3,4-dichloropropionaniline.

Fig. 6 In utero injection of inflammatory cytokines or adoptive transfer of activated T cells leads to pregnancy loss. In utero injection of inflammatory.

MET/β-catenin complexes during synapse development.

miR-29 Inhibits Bleomycin-induced Pulmonary Fibrosis in Mice

Chronic brain insulin infusion reduces liver TG content independent of changes in body weight and food intake. Chronic brain insulin infusion reduces liver.

Immunohistochemistry of human DLB brains.

Effects of TNF-α, IL-6, and IL-1β on 3T3-L1 adipocyte differentiation

Morphometric analyses of β-cells and immune cells in IDDM rats after successful and nonsuccessful combination therapy with anti–TNF-α and anti-TCR or after.

HGF recruits additional synapsin 1 to MET receptor complex.

Chop deletion preserves β-cell function in P58IPK−/− mice.

Slug/Snai2 Is a Downstream Mediator of Epidermal Growth Factor Receptor-Stimulated Reepithelialization Donna F. Kusewitt, Changsun Choi, Kimberly M.

Ultrastructure of the sciatic nerve from P60 and P75 control and Miz1ΔPOZ animals reveal signs of demyelination and dysmyelination. Ultrastructure of the.

Western blot analysis shows inhibition of fluorocitrate on glial hyperactivation and functions. Western blot analysis shows inhibition of fluorocitrate.

Morphologic changes induced in immortalized human podocytes after treatment with TGF-β1 (10 ng/mL, right) for 3 days when compared with control cells (left),

SVs with delayed availability for release are derived from bulk and endosomes. SVs with delayed availability for release are derived from bulk and endosomes.

Volume 35, Issue 1, Pages (July 2011)

Glycogen content of rat optic nerves after glucose deprivation and pharmacological manipulation. Glycogen content of rat optic nerves after glucose deprivation.

Phosphorylation of β-catenin at Y142 is required for the HGF-induced increase in Syn-GFP/bassoon and Syn-GFP/PSD-95 clusters. Phosphorylation of β-catenin.

Stress-induced release of inflammatory monocytes from the bone marrow into circulation was attenuated by MTP. Male C57BL/6 mice were injected daily with.

RvD1 increased anti-inflammatory macrophages and Treg cells in the sciatic nerves of EAN rats. RvD1 increased anti-inflammatory macrophages and Treg cells.

Global levels of AcH4 are increased in DRG neurons after peripheral axotomy. Global levels of AcH4 are increased in DRG neurons after peripheral axotomy.

Changes in levels of transcripts encoding inflammatory cytokines and GFAP. The amounts of the PCR cDNA products were obtained from phosphorimager readings.

At 1 month, control and les rats were fed AL or fasted every other day for IF. Representative images of 1 μm sections, with electron micrograph insets.

Exogenous NR2B-expressing cells are more dynamic than control or exogenous NR2A-expressing cells. Exogenous NR2B-expressing cells are more dynamic than.

PNU enhances Ca2+ flux mediated by an engineered variant of the human α7 nAChR. PNU enhances Ca2+ flux mediated by an engineered variant.

5FU-induced specific activation of CD8+ T cells.

Depletion of Gr-1+ neutrophils by systemic anti-Gr-1 treatment prevents exacerbated neurodegeneration in RAG1-KO mice. Depletion of Gr-1+ neutrophils by.

Expression of IFN-λs, IFN-λR1, and IL-10R2 in Xenopus tissues after stimulation in vivo with poly(I:C). Expression of IFN-λs, IFN-λR1, and IL-10R2 in Xenopus.

Cytokines and cytokine receptors involved in type I immunity in tuberculosis. Cytokines and cytokine receptors involved in type I immunity in tuberculosis.

Repulsive Guidance Molecule-a Is Involved in Th17-Cell-Induced Neurodegeneration in Autoimmune Encephalomyelitis Shogo Tanabe, Toshihide Yamashita Cell.

A, B, 5-HT1A immunoreactivity in hippocampal dendrites (CA3) of saline-treated (A) and fluoxetine-treated (B) rats. A, B, 5-HT1A immunoreactivity in hippocampal.

Presentation transcript:

Exogenous RvD1 treatment attenuated EAN Exogenous RvD1 treatment attenuated EAN. EAN rats were treated with RvD1 (5 μg/kg/d, i.p.) or vehicle (0.9% endotoxin-free saline) from day 10 to day 22 after immunization. Exogenous RvD1 treatment attenuated EAN. EAN rats were treated with RvD1 (5 μg/kg/d, i.p.) or vehicle (0.9% endotoxin-free saline) from day 10 to day 22 after immunization. A, Neurological signs of EAN and body weight were monitored daily (n = 6). B, Sciatic nerves of EAN rats were removed at day 22 for electron microscopy analysis and representative electron micrographs are shown. Arrows indicate axon demyelination (n = 3). C, Representative immunohistochemistry staining and semiquantification of inflammatory cell infiltration in the sciatic nerves of EAN rats (n = 3). D, mRNA levels of IFN-γ, TNF-α, IL-1β, IL-17, TGF-β, and IL-12p35 were measured in the sciatic nerves of EAN rats (n = 3). Representative data from at least two independent experiments are shown. Error bars indicate SEM. *p < 0.05. Bangwei Luo et al. J. Neurosci. 2016;36:9590-9603 ©2016 by Society for Neuroscience