Resistance mechanism for ibrutinib in marginal zone lymphoma

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Prolonged lymphocytosis during ibrutinib therapy is associated with distinct molecular characteristics and does not indicate a suboptimal response to therapy.

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Resistance mechanism for ibrutinib in marginal zone lymphoma by Narendranath Epperla, Arwa Y. Shana’ah, Dan Jones, Beth A. Christian, Sabarish Ayyappan, Kami Maddocks, and Jennifer A. Woyach BloodAdv Volume 3(4):500-502 February 26, 2019 © 2019 by The American Society of Hematology

Bone marrow aspirate and biopsy (postibrutinib). Bone marrow aspirate and biopsy (postibrutinib). Large cells noted on bone marrow aspirate (A; magnification ×100, Wright Giemsa stain) and (B; magnification ×40, hematoxylin and eosin stain). Narendranath Epperla et al. Blood Adv 2019;3:500-502 © 2019 by The American Society of Hematology