Decision Support Portfolio NAVIFY Decision Support Portfolio Decision support software with 120 years of medical innovation rooted in science 1

Increasing medical complexities demand new tools and approaches that enable personalised healthcare Complexity Need Disease Research has identified ~1.2 million mutations from more than 20 tumour types1 New research and development approaches Diagnosis An estimated 60%-70% of decision-making in healthcare is influenced by diagnostic testing2 Comprehensive diagnostics are essential to personalised care Treatment >500 pharmaceutical treatments exist for cancer and conditions related to cancer3 Better awareness of and access to myriad treatment options Workflow Patient information resides in disparate sources and formats across specialty teams More streamlined and efficient clinical workflow Applying technology to Roche’s oncology care expertise As Roche, we are uniquely positioned to deliver on the promise of personalized healthcare. Roche and our partners are well positioned to provide digital health and decision support solutions for clinical and R&D applications. Advances in science, medicine and technology result in increasing complexity: The diseases are getting more and more complex, and physicians need to drill down further to get to subtype, specific classification, genomic signature and other elements that make up the disease and the diagnosis. To get there, your multidisciplinary teams go through comprehensive diagnostic workups using all kinds of modalities: clinical chemistry, immuno, molecular, tissue, sequencing and of course imaging: ultrasound, x-ray, MRIs and PET scans. You need to answer with a very unique and appropriate, maybe even personalized, treatment. A team of different disciplines working hand-in-hand is a challenge to optimize. You want to ensure everyone has the right information at the right time to progress to a treatment plan for a patient. 1 Cell. “Cumulative Haploinsufficiency and Triplosensitivity Drive Aneuploidy Patterns to Shape the Cancer Genome.” November 2013. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891052/#R3 (accessed November 13, 2018) 2 National Academies of Sciences, Engineering, and Medicine. 2018. Improving Cancer Diagnosis and Care: Patient Access to Oncologic Imaging and Pathology Expertise and Technologies: Proceedings of a Workshop. Washington, DC: The National Academies Press. https://doi.org/10.17226/25163 (accessed November 7, 2018) 3 National Institutes of Health National Cancer Institute. “A to Z List of Cancer Drugs.” https://www.cancer.gov/about-cancer/treatment/drugs?redirect=true (accessed October 18, 2018) 2

Looking at the disease and the patient at the same time Present Improved data Present Scientists have begun to understand, target and diagnose illnesses on a molecular level. Cancer is not one disease but the result of innumerable genetic mutations. There are 250 to 300 types and subtypes of cancer.    The approach to treatment has fundamentally changed. Doctors can identify the drivers of the disease and therefore better predict how well a patient is going to respond to a treatment. With the help of sophisticated diagnostic tests and tools, specific genetic defects or other malfunctions can be detected and treated. But our understanding continues to grow. The experiences of millions of patients are captured and stored but difficult to access for understanding about whether or how treatments can be improved. Looking at the disease and the patient at the same time 3

use all relevant available medical data to personalise healthcare Future Individualised treatment Targeted therapy Genomic profile Real-world data Evidenced-based data NAVIFY Portfolio use all relevant available medical data to personalise healthcare Future In an era of digital technology, we should be able to increasingly tailor medical treatment to the needs of individuals and small groups of patients. Far more information is captured and stored and should be analyzed to learn how diseases manifest themselves and how patients experience them day to day. Combined with a deeper understanding of molecular science and new methods for diagnostics, this development could bring disruptive change to how we research, develop, approve and pay for medicines, as well as how patients and their physicians make decisions about whether, when and how to treat illnesses.   With NAVIFY® portfolio, the future is here. 4

NAVIFY Decision Support portfolio Clinical and scientific actionable insights drive personalised healthcare Electronic Medical Records Diagnostics (LIS) Molecular data NAVIFY Portfolio Imaging (PACS) Clinical trials Publications Digital pathology Disparate data sets are integrated within NAVIFY portfolio and leveraged by physicians for new insights. Tumor board teams are empowered to confidently decide on treatment options. As a result of patient-specific and other relevant data available in a single dashboard, clinicians are better able to target therapies, delivering meaningful, value-based outcomes that add to the collective knowledge for population health efforts. At its core, decision support is about driving better patient care. This requires engagement of all relevant specialists (oncologists, pathologists, radiologists, surgeons, nurse navigators, etc.), leveraging meaningful data that helps them make more accurate clinical decisions. 5

NAVIFY Decision Support portfolio Modular. Extendable. Scalable. Value-Added services NAVIFY Clinical Decision Support apps Fully integrate with NAVIFY workflow products Provide timely and relevant, patient-specific, actionable insights to treatment decisions Present additional treatment and research information NAVIFY Workflow products Streamline workflow Increase collaboration Standardise processes NAVIFY platform Provides secure infrastructure Facilitates data management Offers unified core services to power multiple solutions NAVIFY Clinical Decision Support apps Clinical Trial Match* Publication Search* Roche and GE NAVIFY apps Partner apps Third-party apps Analytics NAVIFY Workflow products NAVIFY Tumor Board NAVIFY Workflow solution NAVIFY platform Roche’s vision in decision support begins with the robust, secure, cloud-based technology platform that empowers the development of a suite of decision support products. With security, privacy and analytics built in, NAVIFY Platform can interface with multiple data sets, enabling interoperability with your institution’s EMR, for example. Clinical Decision Support apps are designed to work with multiple NAVIFY workflows. Security Privacy Available now In development *Powered by MolecularMatch, Inc. 6

NAVIFY Tumor Board 7

NAVIFY Tumor Board NAVIFY Clinical Decision Support apps The clinical decision support apps ecosystem is secured and fully integrated with NAVIFY Tumor Board. NAVIFY Clinical Trial Match app* Easily search the largest international trial registries, including ClinicalTrials.gov, European Medicines Agency and private institutions NAVIFY Publication Search app* Effortlessly search more than 300,000 publications across PubMed, American Society of Clinical Oncology and American Association of Cancer Research. A cloud-based workflow product that securely integrates and displays relevant aggregated data into a single, holistic patient dashboard for oncology care teams to review, align and decide on the optimal treatment for the patient. In NAVIFY Tumor Board, a comprehensive dashboard for cancer care teams integrates all the disparate pieces of clinical data from multiple data sets and specialties into one place built for collaboration. The clinical decision support apps ecosystem is secured and fully integrated with NAVIFY Tumor Board, supporting oncology care teams in making treatment decisions for patients. 8 *Powered by MolecularMatch, Inc.

NAVIFY Tumor Board Benefits that improve MDT effectiveness and relevance Collaboration among specialists Increased workflow efficiency NAVIFY Tumor Board could shorten MDT preparation time for oncologists by as much as 53 percent. 1 Comprehensive patient overview MDT decision follow-up Standardisation across MDT Patient data security NAVIFY Tumor Board has all patient data aggregated in one place and visible to members of the care team so that clinicians can collaborate efficiently. NAVIFY Tumor Board integrates data from silos via the DIP, has tools to structure presentations and streamlines workflow so that clinicians can prepare tumor boards faster and accurately. NAVIFY Tumor Board documents treatment decisions and keeps a timeline that shows patients' histories so that clinicians can track patient treatments. NAVIFY Tumor Board has apps powered by a third party that strive to provide the latest scientific and clinical trial data. These align with holistic patient views so that clinicians can treat patients, not their diseases. *Improved workflow efficiency with shorter tumor board preparation time for oncologists (-53%), radiologists (-12%) and surgeons (-8%). 1Journal of Pathology Informatics. “A new software platform to improve multi-disciplinary tumor board workflows and user satisfaction: A pilot study.” July 2018. 9

NAVIFY NAVIFY Knowledge-Complete Clinical Trial Match app* Publication Search app* All in one place Unbiased results Search in real-time Current Information Patient-specific searches based on Age Gender Biomarkers Tumour information Current information in real-time Trusted, curated databases Integrated functionality All in one place Patient-specific results based on Age Biomarkers Tumour information Stage Genomic alterations Tumour location Stage Genomic alterations Roche has engineered BOTH apps, leveraging curated content from MolecularMatch. Knowledge-Complete NAVIFY products leverage vendor-agnostic external data to provide relevant information to customers in order to enable better clinical decision making Results typically returned in seconds** | Results can be filtered and pinned into NAVIFY Tumor Board patient presentations *Powered by MolecularMatch, Inc. 10 ** Depends on connection speeds

NAVIFY Clinical Decision Support apps ecosystem Application Program Interface (API) NAVIFY apps NAVIFY Clinical Trial Match app* NAVIFY Publication Search app* More NAVIFY apps NAVIFY Clinical Decision Support apps Partner apps Fully integrated with NAVIFY Tumor Board, these apps deliver intelligent information and options for each patient in one place within the MDT. Partner app 1 Partner app 2 Third- party apps TBD Software Development Kit (SDK) Built on our secure platform, the NAVIFY apps ecosystem delivers intelligent decision support to oncology care teams. It securely integrates and federates the most relevant scientific research and medical data to arm clinicians with additional treatment information and options for each patient. The NAVIFY apps ecosystem is expanding its selection of integrated apps. Apps enhance NAVIFY Workflow products Available now In development *Powered by MolecularMatch, Inc. 11

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