Airway remodeling-associated mediators in moderate to severe asthma: Effect of steroids on TGF-β, IL-11, IL-17, and type I and type III collagen expression

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Airway remodeling-associated mediators in moderate to severe asthma: Effect of steroids on TGF-β, IL-11, IL-17, and type I and type III collagen expression Jamila Chakir, PhDa, Joanne Shannon, MDb, Sophie Molet, PhDb, Motonori Fukakusa, MDb, Jack Elias, MDc, Michel Laviolette, MDa, Louis-Philippe Boulet, MDa, Qutayba Hamid, MD, PhDb Journal of Allergy and Clinical Immunology Volume 111, Issue 6, Pages 1293-1298 (June 2003) DOI: 10.1067/mai.2003.1557 Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 1 Comparison of TGF-β immunoreactivity in the bronchial submucosa of control subjects, patients with mild asthma, and patients with moderate-to-severe asthma (before and after the 2-week course of oral corticosteroids). Journal of Allergy and Clinical Immunology 2003 111, 1293-1298DOI: (10.1067/mai.2003.1557) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 2 A, Comparison of IL-11 immunoreactivity in the bronchial submucosa of control subjects, patients with mild asthma, and patients with moderate-to-severe asthma (before and after the 2-week course of oral corticosteroids). B, Comparison of IL-11 immunoreactivity in the bronchial epithelium of control subjects, patients with mild asthma, and patients with moderate-to-severe asthma (before and after the 2-week course of oral corticosteroids). Journal of Allergy and Clinical Immunology 2003 111, 1293-1298DOI: (10.1067/mai.2003.1557) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 3 A, Comparison of IL-17 immunoreactivity in the bronchial submucosa of control subjects, patients with mild asthma, and patients with moderate-to-severe asthma (before and after the 2-week course of oral corticosteroids). B, Comparison of IL-17 immunoreactivity in the bronchial epithelium of control subjects, patients with mild asthma, and patients with moderate-to-severe asthma (before and after the 2-week course of oral corticosteroids). Journal of Allergy and Clinical Immunology 2003 111, 1293-1298DOI: (10.1067/mai.2003.1557) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 4 Immunoreactivity of type I collagen in the submucosa of control subjects, patients with mild asthma, and patients with moderate-to-severe asthma (before and after the 2-week course of oral corticosteroids). Journal of Allergy and Clinical Immunology 2003 111, 1293-1298DOI: (10.1067/mai.2003.1557) Copyright © 2003 Mosby, Inc. Terms and Conditions