Viperin Poisons Viral Replication Lisa F.P. Ng, Julian A. Hiscox  Cell Host & Microbe  Volume 24, Issue 2, Pages 181-183 (August 2018) DOI: 10.1016/j.chom.2018.07.014 Copyright © 2018 Elsevier Inc. Terms and Conditions

Figure 1 Viperin Restricts Virus Replication during the Acute Phase of Infection via ddhCTP Upon infection of mammalian cells, the presence of viral RNA in the cytoplasm can be detected by pathogen receptors such as interferon-stimulated genes (ISGs). This leads to the activation of signaling cascades that regulate interferon regulatory factors (IRFs) to induce type I IFN expression. Secretion of type I IFNs to their receptors will then induce the regulation of a positive feedback loop for type I IFN production via IRFs. Viperin is induced and targeted to the ER via the N-terminal amphipathic α-helical domain. This then triggers the catalysis of cytidine triphosphate (CTP) into a structurally similar analog, 3′-deoxy-3′,4’-didehydro-CTP (ddhCTP), through CMPK2 using 5′-deoxyadenosine (5′-dA). Cell Host & Microbe 2018 24, 181-183DOI: (10.1016/j.chom.2018.07.014) Copyright © 2018 Elsevier Inc. Terms and Conditions