M-MDSC:mast cell cross-talk in the regulation of TNFα production.

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M-MDSC:mast cell cross-talk in the regulation of TNFα production. M-MDSC:mast cell cross-talk in the regulation of TNFα production. A, 2 × 105 M-MDSCs were cultured with an equal number of resting (mast cell NS) or IgE/Ag-activated (mast cell Ag) BMMCs derived from wt (black bars), tnf-α−/− (gray bars), or cd40l−/− (white bars) mice. TNFα levels in the supernatants collected after 24 hours of coculture were measured by ELISA. Data are the mean + SEM of three independent experiments. nd, not detectable. B, anti–CD3-stimulated responder splenocytes were cocultured with M-MDSCs and/or resting or IgE/Ag-activated BMMCs. The proliferation assay was performed in the presence of 10 μg/mL of neutralizing anti-TNFα antibody. Mean + SEM of three independent experiments are shown as percentage of divided CD4+ T cells (left) and nitrites production (right). *, P < 0.05. C, proliferation assay (as in B) was performed in the presence of tnf-α−/− BMMCs, and results were compared with the ones obtained with wt BMMCs. One representative of three independent experiments is shown in terms of nitrites levels. *, P < 0.05. MC, mast cell. Luca Danelli et al. Cancer Immunol Res 2015;3:85-95 ©2015 by American Association for Cancer Research