The protective effects of catalase and pyruvate on cysteine neurotoxicity. The protective effects of catalase and pyruvate on cysteine neurotoxicity. Primary.

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The protective effects of catalase and pyruvate on cysteine neurotoxicity. The protective effects of catalase and pyruvate on cysteine neurotoxicity. Primary cortical neurons were cultured in serum-free MEM. Cysteine toxicity was induced by addition of 100 μm cysteine and 0.2 μmCu2+. Neuronal viability was estimated 24 hr later using the MTT assay. Results are expressed as the percentage of surviving neurons compared with control cultures (without addition of cysteine). A, Catalase (10 U/ml), pyruvate (1 mm), and lactate (1 mm) were added immediately before addition of cysteine and Cu2+. Data represent the mean ± SEM of three independent experiments in triplicate.B, Dose–response curve illustrating the neuroprotective effect of pyruvate. Cysteine concentrations were 0, 50, and 100 μm, respectively. Data represent the mean ± SEM of three independent experiments in duplicate. *p < 0.01, significantly different from the control. Xue Feng Wang, and Max S. Cynader J. Neurosci. 2001;21:3322-3331 ©2001 by Society for Neuroscience