NPC-derived oligodendrocytes are maintained long term after cuprizone challenge. NPC-derived oligodendrocytes are maintained long term after cuprizone.

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NPC-derived oligodendrocytes are maintained long term after cuprizone challenge. NPC-derived oligodendrocytes are maintained long term after cuprizone challenge. A, Density of YFP+ and YFP− subpopulations of CC1+ oligodendrocytes and Sox10+ oligodendroglia adjacent to the SVZ in rostral and caudal segments of the CC of Nestin:YFP mice assessed at 6 and 14 weeks of recovery after cuprizone withdrawal. B, The relative density of NPC-derived CC1+ oligodendrocytes expressed as a percentage of NPC-derived Sox10+ oligodendroglia revealed that differentiation did not differ between rostral or caudal segments between 6 and 14 weeks of recovery. Two-way ANOVA with Bonferroni's post hoc analysis did not reveal any statistically significant effects. C, The relative density of pOPC-derived CC1+ oligodendrocytes expressed as a percentage of pOPC-derived Sox10+ oligodendroglia was significantly higher at 14 weeks compared with 6 weeks of recovery in rostral and caudal segments. Two-way ANOVA with Bonferroni's post hoc analysis revealed an overall statistically significant effect of the recovery time point (**p < 0.01), and a specific effect of the recovery time point for both rostral and caudal segments (*p < 0.05). Yao Lulu Xing et al. J. Neurosci. 2014;34:14128-14146 ©2014 by Society for Neuroscience