Taurine as a constituent of mitochondrial tRNAs: new insights into the functions of taurine and human mitochondrial diseases Schematic depiction of modification.

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Taurine as a constituent of mitochondrial tRNAs: new insights into the functions of taurine and human mitochondrial diseases Schematic depiction of modification defects in mitochondrial tRNAs for Leu(UUR) and Lys caused by point mutations related to the mitochondrial encephalomyopathies MELAS (nucleotide positions 3243 or 3271) and MERRF (8344), and possible relationship between taurine dietary deficiency and speculated modification impairment as a cause of cardiomyopathy in the cat. U+ stands for a putative intermediate of τm5(s2)U. IF THIS IMAGE HAS BEEN PROVIDED BY OR IS OWNED BY A THIRD PARTY, AS INDICATED IN THE CAPTION LINE, THEN FURTHER PERMISSION MAY BE NEEDED BEFORE ANY FURTHER USE. PLEASE CONTACT WILEY'S PERMISSIONS DEPARTMENT ON PERMISSIONS@WILEY.COM OR USE THE RIGHTSLINK SERVICE BY CLICKING ON THE 'REQUEST PERMISSIONS' LINK ACCOMPANYING THIS ARTICLE. WILEY OR AUTHOR OWNED IMAGES MAY BE USED FOR NON-COMMERCIAL PURPOSES, SUBJECT TO PROPER CITATION OF THE ARTICLE, AUTHOR, AND PUBLISHER. EMBO J, Volume: 21, Issue: 23, Pages: 6581-6589, First published: 01 December 2002, DOI: (10.1093/emboj/cdf656)