Antigen specificity of direct tumor recognition by HTLV-1 Tax–reactive HTLs. The peptide Tax191-205-reactive HTLs 5G, 8E, and 9B (A-C) and peptide Tax305-319-reactive.

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Antigen specificity of direct tumor recognition by HTLV-1 Tax–reactive HTLs. The peptide Tax191-205-reactive HTLs 5G, 8E, and 9B (A-C) and peptide Tax305-319-reactive HTLs 6D and 25 (D and E) produced IFN-γ as the result of recognizing antigen on restricted... Antigen specificity of direct tumor recognition by HTLV-1 Tax–reactive HTLs. The peptide Tax191-205-reactive HTLs 5G, 8E, and 9B (A-C) and peptide Tax305-319-reactive HTLs 6D and 25 (D and E) produced IFN-γ as the result of recognizing antigen on restricted HLA class II allele–positive HTLV-1-infected T-cell lymphoma cell line presenting the naturally processed epitope. Production of IFN-γ was inhibited by anti-HLA-DR mAb L243 (A-D) or anti-HLA-DQ mAb SPV-L3 (E) and could not be detected using HTLV-1-negative EBV-LCLs, HLA class II fully allogeneic HTLV-1+ T-cell lymphoma cell lines, and HTLV-1-negative HLA class II Jurkat T cell lymphoma. Columns, means of triplicate determinations; bars, SD. Columns without bars had SD <10% the value of the mean. Representative of two experiments that were done under the same conditions. Hiroya Kobayashi et al. Clin Cancer Res 2006;12:3814-3822 ©2006 by American Association for Cancer Research