A, scheme of the APC cDNA and the mutant APC cDNAs which were used for reporter gene assays. A, scheme of the APC cDNA and the mutant APC cDNAs which were.

Slides:

Advertisements

Similar presentations

Transcription control elements (DNA sequences) are binding sites for transcription factors, proteins that regulate transcription from an associated.

Advertisements

RASSF2DSARAH-GF (b) MST1-F (a) M F G 70 kD a 55 kD b 36 kD

Nephrin mutants enhance ATF6‐luciferase reporter activity

Constitutive NF-κB activation by the t(11;18)(q21;q21) product in MALT lymphoma is linked to deregulated ubiquitin ligase activity Honglin Zhou, Ming-Qing.

Volume 6, Issue 5, Pages (November 2004)

HMGA2 is a SUMOylation target.

Enhanced DNA damage in IDH1 mutant glioma cells.

Implications of somatic mutations in the AML1 gene in radiation-associated and therapy-related myelodysplastic syndrome/acute myeloid leukemia by Hironori.

The N‐terminus and SH2 domain of SOCS‐1 contribute to inhibition of JAK1 and JAK2 kinase activity. The N‐terminus and SH2 domain of SOCS‐1 contribute to.

Regulation of Wnt Signaling by Sox Proteins

Volume 7, Issue 5, Pages (May 2001)

Pirh2 promotes p73 ubiquitination in vivo.

Characterization of W1745C and S1783A: 2 novel mutations causing defective collagen binding in the A3 domain of von Willebrand factor by Anne F. Riddell,

Volume 9, Issue 2, Pages (January 1999)

FAS1 domain protein inhibits association of αvβ3 integrin with VEGFR-2 and attenuates VEGF165-induced VEGFR-2 phosphorylation. FAS1 domain protein inhibits.

The absence of ADCC by nivolumab in vitro.

MUC1 Oncoprotein Stabilizes and Activates Estrogen Receptor α

Nuclear export of endogenous APC in different cell lines.

(A) Schematic representation of full‐length APC

SYCE2 directly binds to the chromoshadow domain of HP1α.

MUC1 Oncoprotein Stabilizes and Activates Estrogen Receptor α

Expression of SYCE2 inhibits the interaction of HP1α with H3K9me3.

Chromosome 8 cDNA microarray gene expression profile of the amplified regions of 8p11–12 in SUM-44, -52, and -225 cells versus MCF10A HME control cells.

mTORC1- and mTORC2-activating mutations in MTOR and RHEB

Figure 4 DNM1 mutations affect protein levels and self-dimerization (A) HeLa cells were transfected with green fluorescent protein (GFP)-tagged mutant.

IRS-1 and -2 expression in four mesangial cell lines from different D-NOD (A and B) and ND-NOD (C and D) mice. IRS-1 and -2 expression in four mesangial.

Lysine residues in the cytoplasmic region of TfR are involved in the MARCH8-induced downregulation of TfR. Lysine residues in the cytoplasmic region of.

co-IP of LEDGF/p75 and MeCP2.

FOXO3a phosphorylation and expression.

Key functional sites of SPINDLIN1 could be phosphorylated by Aurora-A.

Evaluation of top candidate clones for selective killing in bispecific antibody format. Evaluation of top candidate clones for selective killing in bispecific.

Constitutive NF-κB activation by the t(11;18)(q21;q21) product in MALT lymphoma is linked to deregulated ubiquitin ligase activity Honglin Zhou, Ming-Qing.

Identification of NSC as a FADD-kinase inhibitor.

Mapping the Pirh2 and p73 interaction sites.

Interaction of MAPJD with E-box sequence of the RIOK1 gene.

Protein expression profile in a dasatinib-resistant cell line.

Competition between FLYWCH1/β-catenin and TCF4/β-catenin complexes for their interaction to Tcf-DNA-binding sites. Competition between FLYWCH1/β-catenin.

DNA damage signaling regulates mutant p53 ubiquitination.

SATB2-AS1 repressed Snail transcription depending on SATB2-mediated recruitment of HDAC1. SATB2-AS1 repressed Snail transcription depending on SATB2-mediated.

NF-kB binds to the NF-κB binding site immediately adjacent to the AT-rich regulatory region. NF-kB binds to the NF-κB binding site immediately adjacent.

PELP1 regulates the expression and activities of MMPs in ER-negative cells. PELP1 regulates the expression and activities of MMPs in ER-negative cells.

MAPJD expression in lung cancers.

Effect of expressing an activated mutant (Rac V12) and an inactivated mutant (Rac N17) of Rac on PTHRP gene expression levels and on JNK activation. Effect.

CXCR4 expression levels of MDA-MB-231 cells at 48 hours posttransfection of CXCR4 siRNAs. CXCR4 expression levels of MDA-MB-231 cells at 48 hours posttransfection.

Effects of visfatin on the cell proliferation and phosphorylation of ERK, Akt, and GSK-3β proteins in HCC cells. Effects of visfatin on the cell proliferation.

Expression of CRC stem cell markers and L1 in CRC cells.

Effect of UV irradiation on PTHRP gene expression.

Targeting DCLK1 by miRNA-137.

PHF10 acts as a transcriptional repressor.

EGF-induced HPSE nucleolar localization induces Topo I activity in 231BR3 cells. EGF-induced HPSE nucleolar localization induces Topo I activity in 231BR3.

A, gel retardation assay in colon cancer cell line SW480.

TET2 interacts with KLF1 transcription factor.

Ligation efficiency is abrogated with increasing concentration of antibodies against NHEJ proteins. Ligation efficiency is abrogated with increasing concentration.

Carcinoma cell–secreted IL-1 induces PGE2 production in MSCs

CCR5 enhances both HDR and SSA DNA repair.

Enhanced expression of Cap43 gene by nickel in breast cancer cell lines. Enhanced expression of Cap43 gene by nickel in breast cancer cell lines. Expression.

N1 decoys differently inhibit ligand-induced NOTCH signaling.

SAHA blocks IR-induced increase of RAD51 protein in MM cells.

Effect of bevacizumab on the proliferation of A2780 cells.

A, Proportion for different in silico predictions at the RNA level.

Effect of MIF siRNA on the production of MMP-13 induced by LPA

FIH hydroxylates G9a and GLP at asparagine residues.

Expression of chemokine receptors in A-498 cell line.

CPGL is a growth suppressor in pancreatic cancer cell lines.

Association of TCTP with Pim-3 in human pancreatic cancer cell lines.

Investigation of reactivity of D14 HLA-A

Depletion of murine Dnmt proteins after 5-Aza-CdR treatment.

An NH2-terminal domain of PALB2, distinct from the BRCA2-interacting domain of PALB2, mediates interaction with BRCA1 and assembly of PALB2 nuclear foci.

Expression of MtrE by wild-type and mtr120 mutant strains.

Binding of TCP4-Like Proteins to the SAUR Promoters Is Enhanced by Light Signal or the Lack of PIFs. (A) and (B) Light increases the binding of TCP4 to.

Presentation transcript:

A, scheme of the APC cDNA and the mutant APC cDNAs which were used for reporter gene assays. A, scheme of the APC cDNA and the mutant APC cDNAs which were used for reporter gene assays. APC is a 2843-aa protein, containing a dimerization domain (▨), armadillo repeats, three β-catenin-binding regions ( ), seven 20-aa repeats (□), SAMP repeats (▪), and a basic domain. B, expression analysis of SW948 cell lysates cotransfected with a 1:5 molar ratio (WT-APC:MT-APC). The lysates were separated on a 3% agarose gel, developed with anti-APC antibody (Ab-1), and visualized by chemoluminescence (ECL). Susanne Dihlmann et al. Cancer Res 1999;59:1857-1860 ©1999 by American Association for Cancer Research