D2R activation in D2R-expressing PVT neurons induces an inhibition of tonic firing which is reversed by D2R antagonism. D2R activation in D2R-expressing.

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D2R activation in D2R-expressing PVT neurons induces an inhibition of tonic firing which is reversed by D2R antagonism. D2R activation in D2R-expressing PVT neurons induces an inhibition of tonic firing which is reversed by D2R antagonism. A, IHC for NeuN (red) and GFP (green) in the PVT in a Drd2-EGFP mouse. Scale bar: 100 µm. B, A total of 64% of PVT neurons express GFP in Drd2-EGFP mice. C, All GFP-expressing PVT neurons exhibited a low-threshold rebound spike following recovery to baseline membrane potential from hyperpolarizing injections of current. D, Example trace of a tonically active D2R-expressing PVT neuron. Quinpirole induced an inhibition of action potential firing that was reversed by coapplication of sulpiride. E, Quantification of firing frequency GFP+ neurons. RM ANOVA: Fdrug(2,8) = 12.04, p = 0.0006, **p < 0.01 Bonferroni post hoc. F, Quantification of firing frequency GFP− neurons. RM ANOVA: Fdrug(2,6) = 2.65, p = 0.12. G, Quantification of resting membrane potential GFP+ neurons. RM ANOVA Fdrug(2,8) = 4.0, p = 0.039, *p < 0.05 Bonferroni post hoc. H, Quantification of resting membrane potential GFP− neurons. RM ANOVA Fdrug(2,6) = 3.94, p = 0.048. Black data points show individual mice and red data points show the mean in E–H. PVT, paraventricular nucleus of the thalamus; mHb, medial habenula. Abigail M. Clark et al. eNeuro 2017;4:ENEURO.0227-17.2017 ©2017 by Society for Neuroscience