Podocytopenia and disease severity in IgA nephropathy

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Presentation transcript:

Podocytopenia and disease severity in IgA nephropathy Kevin V. Lemley, Richard A. Lafayette, Massy Safai, Geraldine Derby, Kristina Blouch, Addy Squarer, Bryan D. Myers Kidney International Volume 61, Issue 4, Pages 1475-1485 (April 2002) DOI: 10.1046/j.1523-1755.2002.00269.x Copyright © 2002 International Society of Nephrology Terms and Conditions

Figure 1 Glomerular filtration rate (GFR) in the IgA nephropathy (IgA) and control groups. Kidney International 2002 61, 1475-1485DOI: (10.1046/j.1523-1755.2002.00269.x) Copyright © 2002 International Society of Nephrology Terms and Conditions

Figure 2 Ficoll sieving curves in individual patients with IgA nephropathy (thin lines), representing the relationship between the fractional clearance of a given Ficoll and its molecular radius. The normal range for Ficoll sieving curves in our laboratory (2 SD above and below the mean value) is indicated by the two heavy dashed lines. The normal range is limited because urinary Ficoll is usually not detected for molecular radii>56 Å. Kidney International 2002 61, 1475-1485DOI: (10.1046/j.1523-1755.2002.00269.x) Copyright © 2002 International Society of Nephrology Terms and Conditions

Figure 3 Relationship between the fractional clearance of albumin (left) and IgG (right) and the fraction of filtrate passing through nonselective shunts (ωθ) in the subjects with IgA nephropathy. Kidney International 2002 61, 1475-1485DOI: (10.1046/j.1523-1755.2002.00269.x) Copyright © 2002 International Society of Nephrology Terms and Conditions

Figure 4 GFR in the patients with IgA nephropathy plotted against the percent of glomeruli manifesting global sclerosis (r = -0.83,P < 0.001). Kidney International 2002 61, 1475-1485DOI: (10.1046/j.1523-1755.2002.00269.x) Copyright © 2002 International Society of Nephrology Terms and Conditions

Figure 5 Relationship of GFR (A), percentage of global sclerosis (B) and shunt magnitude, ωθ (C) to the number of endocapillary cells per glomerulus in patients with IgA nephropathy. Kidney International 2002 61, 1475-1485DOI: (10.1046/j.1523-1755.2002.00269.x) Copyright © 2002 International Society of Nephrology Terms and Conditions

Figure 6 Relationship of GFR (A), percentage of global sclerosis (B) and shunt magnitude, ωθ (C) to the number of podocytes per glomerulus in patients with IgA nephropathy. Kidney International 2002 61, 1475-1485DOI: (10.1046/j.1523-1755.2002.00269.x) Copyright © 2002 International Society of Nephrology Terms and Conditions