Cardioprotective effects and the mechanisms of terminal warm blood cardioplegia in pediatric cardiac surgery Yoshiya Toyoda, MD, Masahiro Yamaguchi,

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Presentation transcript:

Cardioprotective effects and the mechanisms of terminal warm blood cardioplegia in pediatric cardiac surgery Yoshiya Toyoda, MD, Masahiro Yamaguchi, MD, Naoki Yoshimura, MD, Shigeteru Oka, MD, Yutaka Okita, MD The Journal of Thoracic and Cardiovascular Surgery Volume 125, Issue 6, Pages 1242-1249 (June 2003) DOI: 10.1016/S0022-5223(02)73240-6

Figure 1 Oxygen extraction during initial 60 minutes of reperfusion after aortic crossclamp release. All results are shown as mean ± standard error of mean for each group. The Journal of Thoracic and Cardiovascular Surgery 2003 125, 1242-1249DOI: (10.1016/S0022-5223(02)73240-6)

Figure 2 Lactate extraction rate during initial 60 minutes of reperfusion after aortic crossclamp release. All results are shown as mean ± standard error of mean for each group. Significant differences: *P < .05 vs control. The Journal of Thoracic and Cardiovascular Surgery 2003 125, 1242-1249DOI: (10.1016/S0022-5223(02)73240-6)

Figure 3 Serum concentration of cardiac troponin T 0, 1, 3, 6, and 18 hours after aortic crossclamp release. All results are shown as mean ± standard error of mean for each group. Significant differences: *P < .05 vs control. The Journal of Thoracic and Cardiovascular Surgery 2003 125, 1242-1249DOI: (10.1016/S0022-5223(02)73240-6)

Figure 4 Serum concentration of heart-type fatty acid binding protein (FABP) 0, 1, 2, and 3 hours after the aortic crossclamp release. All results are shown as mean ± standard error of mean for each group. Significant differences: *P < .05 vs control. The Journal of Thoracic and Cardiovascular Surgery 2003 125, 1242-1249DOI: (10.1016/S0022-5223(02)73240-6)

Figure 5 Effects of TWBCP in younger patients (age ≤ 2 years). Lactate extraction rate during initial 30 minutes of reperfusion after aortic crossclamp release. All results are shown as mean ± standard error of mean for each group. Significant differences: *P < .05 vs control. The Journal of Thoracic and Cardiovascular Surgery 2003 125, 1242-1249DOI: (10.1016/S0022-5223(02)73240-6)

Figure 6 Effects of TWBCP in younger patients (age ≤ 2 years). Serum concentration of cardiac troponin T 0, 1, 3, 6, and 18 hours after aortic crossclamp release. All results are shown as mean ± standard error of mean for each group. The Journal of Thoracic and Cardiovascular Surgery 2003 125, 1242-1249DOI: (10.1016/S0022-5223(02)73240-6)

Figure 7 Effects of TWBCP in patients with cyanosis. Lactate extraction rate during initial 60 minutes of reperfusion after aortic crossclamp release. All results are shown as mean ± standard error of mean for each group. Significant differences: *P < .05 versus control. The Journal of Thoracic and Cardiovascular Surgery 2003 125, 1242-1249DOI: (10.1016/S0022-5223(02)73240-6)

Figure 8 Effects of TWBCP in patients with cyanosis. Serum concentration of cardiac troponin T 0, 1, 3, 6, and 18 hours after aortic crossclamp release. All results are shown as mean ± standard error of mean for each group. The Journal of Thoracic and Cardiovascular Surgery 2003 125, 1242-1249DOI: (10.1016/S0022-5223(02)73240-6)