Total Anomalous Pulmonary Venous Connection: An Analysis of Current Management Strategies in a Single Institution  Camille L. Hancock Friesen, MD, David.

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Presentation transcript:

Total Anomalous Pulmonary Venous Connection: An Analysis of Current Management Strategies in a Single Institution  Camille L. Hancock Friesen, MD, David Zurakowski, PhD, Ravi R. Thiagarajan, MD, Joseph M. Forbess, MD, Pedro J. del Nido, MD, John E. Mayer, MD, Richard A. Jonas, MD  The Annals of Thoracic Surgery  Volume 79, Issue 2, Pages 596-606 (February 2005) DOI: 10.1016/j.athoracsur.2004.07.005 Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Intervention and outcomes schema for total anomalous pulmonary venous connection (TAPVC). The clinical course of each patient is stratified according to variables that significantly influenced survival; two ventricles versus one ventricle, obstructed versus unobstructed pulmonary veins, and type of repair. aDenotes 1 patient missing from subsequent analysis as there was no record of the type of repair performed; the patient had single-ventricle anatomy with unobstructed TAPVC and a complex, elective repair, and suffered early mortality. The Annals of Thoracic Surgery 2005 79, 596-606DOI: (10.1016/j.athoracsur.2004.07.005) Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Kaplan-Meier estimated survival in total anomalous pulmonary venous connection for the entire cohort of 123 patients. For the entire cohort, Kaplan-Meier estimated 1-month survival is 85% (95% confidence interval [CI], 80% to 90%), 1-year survival is 75% (95% CI, 68% to 83%) and 3-year survival is 73% (95% CI, 66% to 80%). The error bar represents the 95% CI. The Annals of Thoracic Surgery 2005 79, 596-606DOI: (10.1016/j.athoracsur.2004.07.005) Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Kaplan-Meier survival in total anomalous pulmonary venous connection for single-ventricle versus two-ventricle patients. For two-ventricle patients (solid circle), the estimated 1-month survival is 95% (95% confidence interval [CI], 90% to 100%), 1-year survival is 89% (95% CI, 84% to 94%) and 3-year survival is 86% (95% CI, 81% to 92%). For one-ventricle patients (open circle), the estimated 1-month survival is 65% (95% CI, 53% to 77%) and 1- and 3-year estimated survival is 47% (95% CI, 35% to 59%). Survival time was significantly shorter in single-ventricle patients (p < 0.0001, log-rank test = 19.68). Error bar represents 95% CI. The Annals of Thoracic Surgery 2005 79, 596-606DOI: (10.1016/j.athoracsur.2004.07.005) Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 Kaplan-Meier survival in total anomalous pulmonary venous connection for patients with a single ventricle in the presence (open circle) or absence (solid circle) of prerepair pulmonary venous obstruction. Survival in single-ventricle patients was significantly compromised in patients with prerepair pulmonary venous obstruction (p < 0.01, log-rank test = 5.69). Error bars for patients with obstruction represent a 95% confidence interval (CI) of 16% to 46%, and for patients without obstruction, a 95% CI of 54% to 82%. The Annals of Thoracic Surgery 2005 79, 596-606DOI: (10.1016/j.athoracsur.2004.07.005) Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions