Galactose-alpha-1,3-galactose sensitization is a prerequisite for pork-kidney allergy and cofactor-related mammalian meat anaphylaxis Jörg Fischer, MD,

Slides:

Advertisements

Similar presentations

Joint modeling of parentally reported and physician-confirmed wheeze identifies children with persistent troublesome wheezing Danielle C.M. Belgrave, MSc,

Advertisements

Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.

Detection of novel occupational wood allergens in locust wood dust (Robinia pseudoacacia L.) Sabine Kespohl, PhD, Rolf Merget, MD, Axel Overlack, MD,

Repeated low-dose intradermal allergen injection suppresses allergen-induced cutaneous late responses Giuseppina Rotiroti, MD, Mohamed Shamji, PhD, Stephen.

Linear epitope mapping of peanut allergens demonstrates individualized and persistent antibody-binding patterns Christian S. Hansen, PhD, Martin Dufva,

The use of serum-specific IgE measurements for the diagnosis of peanut, tree nut, and seed allergy Jennifer M. Maloney, MD, Magnus Rudengren, BSc, Staffan.

Relevance of specific IgE antibody titer to the prevalence, severity, and persistence of asthma among 19-year-olds in northern Sweden Matthew S. Perzanowski,

Allergen immunotherapy: A practice parameter third update

High-titer IgE antibody specific for pollen allergens in northern California is associated with both wheezing and total serum IgE Elizabeth A. Erwin,

Delayed anaphylaxis, angioedema, or urticaria after consumption of red meat in patients with IgE antibodies specific for galactose-α-1,3-galactose Scott.

Kyoung-Bok Min, MD, PhD, Jin-Young Min, PhD

Delayed clinical and ex vivo response to mammalian meat in patients with IgE to galactose-alpha-1,3-galactose Scott P. Commins, MD, PhD, Hayley R. James,

Asian ladybugs (Harmonia axyridis): A new seasonal indoor allergen

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD

Giant ragweed specific immunotherapy is not effective in a proportion of patients sensitized to short ragweed: Analysis of the allergenic differences.

Relevance of specific IgE antibody titer to the prevalence, severity, and persistence of asthma among 19-year-olds in northern Sweden Matthew S. Perzanowski,

Major rabbit allergen Ory c 3: What could be its possible role as a sensitizing agent in real life? Gennaro Liccardi, MD, Antonello Salzillo, MD, Maria.

Evaluation of BCG administration as an adjuvant to specific immunotherapy in asthmatic children with mite allergy Andrea Cohon, MD, L. Karla Arruda,

Julie Wang, MD, James H. Godbold, PhD, Hugh A. Sampson, MD

Linear epitope mapping of peanut allergens demonstrates individualized and persistent antibody-binding patterns Christian S. Hansen, PhD, Martin Dufva,

Diagnosis of red meat allergy with antigen-specific IgE tests in serum

Diagnosing IgE-mediated hypersensitivity to sesame by an immediate-reading “contact test” with sesame oil Cristiana Alonzi, MD, Paolo Campi, MD, Francesco.

Is 9 more than 2 also in allergic airway inflammation?

Reassessing the role of hyaluronidase in yellow jacket venom allergy

Allergen sensitization in a birth cohort at midchildhood: Focus on food component IgE and IgG4 responses Jeffrey M. Wilson, MD, PhD, Lisa Workman, BA,

In vivo allergenic activity of a hypoallergenic mutant of the major fish allergen Cyp c 1 evaluated by means of skin testing Nikolaos Douladiris, MD,

Loss of allergenic proteins during boiling explains tolerance to boiled peanut in peanut allergy Paul J. Turner, FRACP, PhD, Sam Mehr, FRACP, Rebekah.

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

Allergy testing in predicting outcome of open food challenge to peanut

IgE in the diagnosis and treatment of allergic disease

Peter M. Wolfgram, MD, David B. Allen, MD

Etiology of asthma exacerbations

Comparable IgE reactivity to natural and recombinant Api m 1 in cross-reactive carbohydrate determinant–negative patients with bee venom allergy Thilo.

ImmunoCAP cellulose displays cross-reactive carbohydrate determinant (CCD) epitopes and can cause false-positive test results in patients with high anti-CCD.

Repeated Episodes of Anaphylaxis with Normal Serum Tryptase but Elevated Levels of Urinary Prostaglandin D2 Phillip Lieberman, MD The Journal of Allergy.

Debra J. Palmer, PhD, Thomas R. Sullivan, BMa&CompSc(Hons), Michael S

Phillip Lieberman, MD, Michael Tankersley, MD

Slow reactive substance of anaphylaxis

Time for a paradigm shift in asthma treatment: From relieving bronchospasm to controlling systemic inflammation Leif Bjermer, MD Journal of Allergy.

Tolerated wasp sting challenge improves health-related quality of life in patients allergic to wasp venom Jörg Fischer, MD, Martin Teufel, MD, Alexandra.

Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management Scott H. Sicherer, MD, Hugh A. Sampson, MD Journal.

Altered metabolic profile in patients with IgE to galactose-alpha-1,3-galactose following in vivo food challenge John W. Steinke, PhD, Shawna L. Pochan,

Allergy to furry animals: New insights, diagnostic approaches, and challenges Jon R. Konradsen, MD, PhD, Takao Fujisawa, MD, PhD, Marianne van Hage, MD,

What is an “eosinophilic phenotype” of asthma?

Cephalosporin Side Chain Cross-reactivity

Anaphylaxis caused by hidden soybean allergens in pillows

Cockroach allergens: Coping with challenging complexity

Autophagy: Nobel Prize 2016 and allergy and asthma research

Higher incidence of pediatric anaphylaxis in northern areas of the United States William J. Sheehan, MD, Dionne Graham, PhD, Lin Ma, MS, Sachin Baxi,

Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment

Advances in the approach to the patient with food allergy

Peach allergy in China: A dominant role for mugwort pollen lipid transfer protein as a primary sensitizer Zhong-Shan Gao, PhD, Zhao-Wei Yang, BSc, Shan-Dong.

Relationship between red meat allergy and sensitization to gelatin and galactose-α-1,3- galactose Raymond James Mullins, MBBS, PhD, FRACP, FRCPA, Hayley.

Spiking venom with rVes v 5 improves sensitivity of IgE detection in patients with allergy to Vespula venom Byrthe Vos, Julian Köhler, Sabine Müller,

Identification of crab proteins that elicit IgE reactivity in snow crab–processing workers Beth V. Gill, MD, Timothy R. Rice, André Cartier, MD, Denise.

Benjamin Chaigne, MD, Hervé Watier, MD, PhD

Reply Journal of Allergy and Clinical Immunology

The role of indoor allergens in chronic allergic disease

Pedro Gamboa, MD, PhD, Rosa Sanchez-Monge, PhD, M

Peanut oral immunotherapy decreases IgE to Ara h 2 and Ara h 6 but does not enhance sensitization to cross-reactive allergens Riikka Uotila, MD, Anna.

Contribution of dust mite and cat specific IgE to total IgE: Relevance to asthma prevalence Elizabeth A. Erwin, MD, Eva Rönmark, PhD, Kristin Wickens,

Päivi M. Salo, PhD, Samuel J. Arbes, DDS, MPH, PhD, Patrick W

Macrolide antibiotics and asthma treatment

Asthma: The past, future, environment, and costs

Repeated low-dose intradermal allergen injection suppresses allergen-induced cutaneous late responses Giuseppina Rotiroti, MD, Mohamed Shamji, PhD, Stephen.

Placental transfer of allergen-specific IgG but not IgE from a specific immunotherapy– treated mother Sabine Flicker, PhD, Katharina Marth, MD, Heinz.

Natural history of cow’s milk allergy

The alpha-gal story: Lessons learned from connecting the dots

Primary prevention of asthma and allergy

Carl Hamsten, MSc, PhD, Thi Anh T

Presentation transcript:

Galactose-alpha-1,3-galactose sensitization is a prerequisite for pork-kidney allergy and cofactor-related mammalian meat anaphylaxis Jörg Fischer, MD, Johanna Hebsaker, Patricia Caponetto, MD, Thomas A.E. Platts-Mills, MD, PhD, Tilo Biedermann, MD Journal of Allergy and Clinical Immunology Volume 134, Issue 3, Pages 755-759.e1 (September 2014) DOI: 10.1016/j.jaci.2014.05.051 Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Percentage of reactive prick-to-prick tests using kidney and muscle meat from pork and beef with raw and cooked samples. Intradermal test with gelatin in 20 α-Gal–sensitized patients, divided into 2 subgroups: patients with only pork-kidney allergy and patients with pork-kidney and additional red meat allergy in their clinical history. ID-test, Intradermal test. Journal of Allergy and Clinical Immunology 2014 134, 755-759.e1DOI: (10.1016/j.jaci.2014.05.051) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 ImmunoCAP inhibition was performed for patients 3 and 5 by pre-incubating sera with increasing dilution of bovine thyroglobulin (square) and pork-kidney extract (triangle) for 12 hours at 4°C and then testing for allergen-specific IgE antibodies to α-GAL (upper row) and pork meat (lower row). The allergen-specific IgEs are displayed as the percentage of the non-incubated titer. Inhibition of >75% was interpreted as complete inhibition of the ImmunoCAP by the substrate used. sIgE, Allergen-specific IgE. Journal of Allergy and Clinical Immunology 2014 134, 755-759.e1DOI: (10.1016/j.jaci.2014.05.051) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions