Long-Term Opioid Therapy for Chronic Noncancer Pain: A Systematic Review and Meta-Analysis of Efficacy and Safety Meredith Noble, MS, Stephen J. Tregear,

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Presentation transcript:

Long-Term Opioid Therapy for Chronic Noncancer Pain: A Systematic Review and Meta-Analysis of Efficacy and Safety Meredith Noble, MS, Stephen J. Tregear, DPhil, Jonathan R. Treadwell, PhD, Karen Schoelles, MD, SM Journal of Pain and Symptom Management Volume 35, Issue 2, Pages 214-228 (February 2008) DOI: 10.1016/j.jpainsymman.2007.03.015 Copyright © 2008 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 1 Flow diagram of study selection. Journal of Pain and Symptom Management 2008 35, 214-228DOI: (10.1016/j.jpainsymman.2007.03.015) Copyright © 2008 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 2 Withdrawal from clinical trial due to adverse events. Journal of Pain and Symptom Management 2008 35, 214-228DOI: (10.1016/j.jpainsymman.2007.03.015) Copyright © 2008 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 3 Withdrawal from clinical trial due to insufficient pain relief. Journal of Pain and Symptom Management 2008 35, 214-228DOI: (10.1016/j.jpainsymman.2007.03.015) Copyright © 2008 U.S. Cancer Pain Relief Committee Terms and Conditions