TOMA does not affect NFTs in posterior hypothalamus or cortex.

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TOMA does not affect NFTs in posterior hypothalamus or cortex. TOMA does not affect NFTs in posterior hypothalamus or cortex. Coronal sections of 8-month-old P301L brain immunized with nonspecific IgG antibody (anti-rhodamine) (A–D) and TOMA (E–H) were immunostained with AT8 (A–C and E–G) and stained with the Gallyas-silver method (D, H). A and E are hippocampus; B–D and F–H are posterior hypothalamus (PH). C–D and G–H are images at higher-magnification showing NFTs (arrows) in PH. Scale bars: A, B, E, F, 100 μm; C, G, 15 μm. Graph represents the number of NFT-positive cells per field in the PH stained with AT8. J–M, PBS-insoluble tau fraction from P301L mice immunized with nonspecific IgG and TOMA was analyzed by ELISA (J, L) and Western blot (K, M) using AT8 (J, K) and PHF-13 (L, M). The gel band intensity immunoreactive to AT8 and PHF-13 (∼56–100 kDa) was quantified and normalized using actin as an internal control. The differences were not statistically significant using Student's t test. Diana L. Castillo-Carranza et al. J. Neurosci. 2014;34:4260-4272 ©2014 by Society for Neuroscience