The proximal kidney tubule is the target for tenofovir-associated nephrotoxicities. The proximal kidney tubule is the target for tenofovir-associated nephrotoxicities.

Slides:

Advertisements

Similar presentations

Tansporters and Disposition of Drugs

Advertisements

Common tubular secretory mechanisms for organic cations and anions

Switch from TDF-based to Elvitegravir-Cobicistat-TAF-FTC Study 109

Glucose handling by the kidney

Figure 2 Glucose handling by the kidney

Andrew M. Hall, MD, PhD, Bruce M

Toxic Nephropathies: Core Curriculum 2010

Volume 75, Issue 11, Pages (June 2009)

Regional sodium handling, urine diuretic levels, and plasma aldosterone in groups with high or low loop diuretic–induced increase in FELi or FENa. Group.

Volume 68, Issue 6, Pages (December 2005)

Apical membrane handling of substances, in this example aminoglycosides, by proximal tubular cells. Apical membrane handling of substances, in this example.

Kidney specific factors that enhance nephrotoxic risk are noted.

Volume 78, Issue 11, Pages (December 2010)

Mitochondria-associated membranes in proximal tubules after ischemia.

Autosomal dominant distal renal tubular acidosis and the AE1 gene

Volume 71, Issue 8, Pages (April 2007)

Post-transplant hypophosphatemia

A ‘complexity’ of urate transporters

Volume 86, Issue 2, Pages (August 2014)

Regulation of renal tubular secretion of organic compounds

Volume 83, Issue 4, Pages (April 2013)

Transcellular movement of organic cations (OCs) and organic anions (OAs) in kidney proximal tubule epithelial cells. Transcellular movement of organic.

Cellular and molecular aspects of drug transport in the kidney

Schematic illustration of the reabsorption of calcium, phosphorus, and magnesium by different segments of the nephron. Schematic illustration of the reabsorption.

Volume 80, Issue 4, Pages (August 2011)

Insulin resistance and hypertension: new insights

Volume 60, Issue 2, Pages (August 2001)

Renal potassium channels: Function, regulation, and structure

Advances in the pathogenesis of HIV-associated kidney diseases

Aminoacidurias: Clinical and molecular aspects

A new regulator of the vacuolar H+-ATPase in the kidney

Volume 72, Issue 4, Pages (August 2007)

Model of proximal ammonia transport.

A and B: Glucose reabsorption via SGLT1 and SGLT2 in normal and diabetic kidney. A and B: Glucose reabsorption via SGLT1 and SGLT2 in normal and diabetic.

Proximal tubule HCO3− reabsorption and H+ secretion.

Pharmacology American Journal of Kidney Diseases

Ammonia secretion by the collecting duct.

Conditions within the kidney that are conducive to C activation.

Drug factors associated with increased risk for nephrotoxicity.

Coordinated control of renal Ca2+ handling

Ca2+ infusion rates during all three protocol versions.

Basolateral transport of drugs.

Drug clearance by metabolism can also decrease with declining kidney function. Drug clearance by metabolism can also decrease with declining kidney function.

A loading dose decreases the time to achieve the target concentration.

Apical transport of drugs in the proximal tubule.

Rates of plasma sodium concentration increase before and after DDAVP administration. Rates of plasma sodium concentration increase before and after DDAVP.

Urea transport across an IMCD cell.

Measured urea permeabilities in the different nephron sections of a rat kidney. Measured urea permeabilities in the different nephron sections of a rat.

Intercalated cells in rat collecting duct.

Intercalated cells are involved in K+secretion in the collecting duct

Urea transporters along the nephron.

Relationship between excess fluid, as determined by the difference between measured and estimated body water, and plasma albumin (R = −0.40, P = 0.011).

Kidney factors that enhance risk for drug-induced nephrotoxicity.

Cisplatin (Cis) nephrotoxicity is, in part, related to its uptake by proximal tubular cells. Cisplatin (Cis) nephrotoxicity is, in part, related to its.

Integrated overview of renal ammonia metabolism.

SGLT-2 mediates glucose reabsorption in the kidney.

Model of major transport processes and regulatory mechanisms in type B intercalated cells. Model of major transport processes and regulatory mechanisms.

Ultrastructural localization of NKCC2 protein in the TAL and macula densa (MD). Ultrastructural localization of NKCC2 protein in the TAL and macula densa.

Distribution of percent consistent facility aspirin use.

Pathophysiologic pathways of hematuria-induced kidney damage.

Analysis of secreted proteins in the discovery panel.

Tubulointerstitial changes and arteriolar hyalinosis in diabetic kidney disease. Tubulointerstitial changes and arteriolar hyalinosis in diabetic kidney.

Annual prevalence of proteinuria, hematuria, and combined proteinuria/hematuria on first screening in junior high school children in Tokyo, Japan between.

Pemetrexed (Pmx) nephrotoxicity may result from proximal tubular cell uptake of drug through apical (folate receptor-α [FR-α]) and basolateral (reduced.

Dose adjustments in patients with CKD are based on the change in the concentration-time profile for the drug of interest. Dose adjustments in patients.

Plasma concentration-time profile after oral administration of a single dose. Plasma concentration-time profile after oral administration of a single dose.

Lithium transport pathways in proximal and distal tubule cells.

Simplistic breakdown of the new MPGN classification using immunofluorescence as the basis and an approach to evaluation when the kidney biopsy indicated.

Sites for absorption, distribution, metabolism, enterohepatic recycling (EHC), and elimination of mycophenolic acid (MPA). Sites for absorption, distribution,

Organ quality (KDPI) of unilaterally discarded, deceased donor kidneys stratified by discard type (n=7625 kidneys), 2000–2015. Organ quality (KDPI) of.

Presentation transcript:

The proximal kidney tubule is the target for tenofovir-associated nephrotoxicities. The proximal kidney tubule is the target for tenofovir-associated nephrotoxicities. Handling of tenofovir (TFV), the active metabolite of tenofovir disoproxil fumarate (TDF) and tenofovir alafenamide fumarate (TAF), by the proximal tubular cells of the kidney. TFV exits the tubular circulation primarily via the organic anion transporter 1 (OAT1) on the basolateral membrane, and after it is within the cell, it exits into the urine via the apical multidrug resistance protein type 4 (MRP 4) and possibly, MRP 2. TAF is more stable in plasma than TDF, with minimal hydrolyses to TFV. The bulk of TAF is rather transported to target cells. MATE1, multidrug and toxin extrusion transporter 1; OCT2, organic cation transporter 2. Mohamed G. Atta et al. CJASN 2019;14:435-444 ©2019 by American Society of Nephrology