Anti-PD-1H Antibody Prevents Graft Versus Host Disease

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Anti-PD-1H Antibody Prevents Graft Versus Host Disease BALB/c Mouse Bone Marrow Derived Cells C57BL/6 Mouse Anti-PD-1H Antibody (MH5A) Graft Versus Host Disease Death Lethal Irradiation Cells isolated from the bone marrow of a BALB/c mouse are transplanted into a lethally irradiated C57BL/6 mouse. While Graft Versus Host Disease (GVHD) normally causes donor T cells to attack and kill a host, the treatment of host mice with a dose of anti-PD-1H antibody was sufficient to prevent GVHD. Adapted from: Flies, D.B., et al. 2011. J. Immunol. 187: 1537. PD-1H is a newly discovered marker related to the CD28 family of molecules, also known as VISTA. It is a negative regulatory molecule that has found on macrphages, dendritic cells, neutrophils, NK cells, and T cells. ®