Replication and meta-analysis of the CHRFAM7A copy number variant in a cohort of clinically characterized and neuropathologically verified individuals

Slides:

Advertisements

Similar presentations

Gene Preference in Maple Syrup Urine Disease Mary M. Nellis, Dean J. Danner The American Journal of Human Genetics Volume 68, Issue 1, Pages (January.

Advertisements

Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part I: Methods and Power Analysis Douglas F. Levinson, Matthew D. Levinson, Ricardo Segurado,

2015 Alzheimer's disease facts and figures Alzheimer's & Dementia: The Journal of the Alzheimer's Association Volume 11, Issue 3, Pages (March.

Capillary dysfunction in Alzheimer's disease

DIAGNOSTIC ACCURACY AND CONFIDENCE IN THE CLINICAL DETECTION OF COGNITIVE IMPAIRMENT IN EARLY-STAGE PARKINSON’S DISEASE Kathryn A. Wyman-Chick, Phillip.

Vladimir S. Fonov, Mahsa Dadar, Xiao Yiming, D. Louis Collins

Are early atrophy patterns in autosomal dominant familial Alzheimer's disease gene- dependent? Kirsi Kinnunen, Natalie Ryan, David Cash, António Bastos.

Relationship between Microstructural Degeneration of the Corpus Callosum, White Matter Hyperintensities, and Motor Function in Cognitively Intact Elderly

Hilkka Liedes, Jyrki Lötjönen, Gerald P. Novak, Mark Forrest Gordon

Comparison of accelerated and nonaccelerated MRI in ADNI: Effects on measures of brain and ventricular volumes and rates of atrophy Kelvin Leung, Casper.

A SYSTEMATIC REVIEW AND META-ANALYSIS COMPARING QUALITY-OF-LIFE RATINGS FROM FAMILY AND PAID CAREGIVERS OF PEOPLE WITH DEMENTIA RESIDING IN CARE HOMES

Mutation frequency of pathogenic genes in familial Alzheimer’s disease in China Jianping Jia, Liyong Wu, Wei Qin, Dan Li, Luxi Shen, Hanzhi Li, Qianqian.

Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Trajectory of multi-dimensional caregiving burden in chinese informal caregivers for dementia: Evidence from exploratory and confirmatory factor analysis.

Interaction network of tau protein, beta-amyloid protein, and amyloid protein precursor under oxidative stress in Alzheimer’s disease Eduardo de Souza/S.

SERUM NEUROFILAMENT LIGHT PROTEIN PREDICTS CLINICAL OUTCOME IN TRAUMATIC BRAIN INJURY Pashtun Shahim, Magnus Gren, Victor Liman, Ulf Andreasson, Niklas.

The differential diagnosis of amnestic mild cognitive impairment and Alzheimer's disease dementia by hippocampal volume measurement with MR in a chinese.

Localization of Hippocampal atrophy in Alzheimer's disease

Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Christine Bredfeldt, Kristen Rice, Lisa Alecxih

SMARTPHONE TECHNOLOGY TO MEASURE HEALTH CHARACTERISTICS IN OFFSPRING OF PATIENTS WITH DEMENTIA: THE IVITALITY PROOF-OF- PRINCIPLE STUDY Liselotte Wijsman,

CANDIDATE GENE STUDIES AND GWAS SUGGEST SUBSTANTIAL GENETIC INFLUENCE ON DEFICITS IN OLFACTORY IDENTIFICATION AMONG PERSONS AT RISK OF AD Marie-Elyse.

Alzheimer's & Dementia: The Journal of the Alzheimer's Association

KETOGENIC DIET EFFECTS ON BRAIN KETONE METABOLISM AND ALZHEIMER'S DISEASE CSF BIOMARKERS Suzanne Craft, Bryan J. Neth, Akiva Mintz, Kiran Sai, Nora Shively,

The effect of using a conditional discrimination procedure to teach name-face relation to a person diagnosed with dementia Hanna S. Steingrimsdottir,

Application of Resource Utilization in Dementia (RUD) instrument in a global setting Anders Wimo, Anders Gustavsson, Linus Jönsson, Bengt Winblad, Ming-Ann.

HYPERGLYCEMIA: PREDISPOSITION FOR MICROEMBOLI, STROKE, AND WHITE MATTER CHANGES Leila Parand, Saif Bushnaq, Yue Wang, Lenora Mathes, Dinesh Jillella,

Marjolein Bulk, Linda van der Graaf, Walid M

Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Japanese brain bank network for neuroscience research

BIOLOGICAL PATHWAYS FOUND IN COMMON BETWEEN ALZHEIMER’S DISEASE AND MAJOR DEPRESSION: A STUDY ON MICRORNA EXPRESSION IN A SYSTEMATIC REVIEW Ana Paula.

Recurrent CNVs Disrupt Three Candidate Genes in Schizophrenia Patients

Community environment and incident dementia: Results from the three-city study Claudine Berr, Laure Anne Gutierrez, Sylvaine Artero, Catherine Helmer,

Pairwise gene-protein association analysis on CSF proteomics in the ADNI-1 cohort Sungeun Kim, Shanker Swaminathan, Kwangsik Ngo, Shannon Risacher, Li.

Effect of hypertension and antihypertensive medication on executive function, brain atrophy, and white matter hyperintensities Shannon L. Risacher, Li.

Prevalence and incidence of clinically diagnosed Alzheimer's disease dementia from 1994 to 2012 in a population study Kumar B. Rajan, Jennifer Weuve,

Practice Notes from the AAAAI

Application of Resource Utilization in Dementia (RUD) instrument in a global setting Anders Wimo, Anders Gustavsson, Linus Jönsson, Bengt Winblad, Ming-Ann.

Volume 376, Issue 9750, Pages (October 2010)

Editorial Board Orthopedic Clinics Volume 48, Issue 3, (July 2017)

Prevalence and incidence of clinically diagnosed Alzheimer's disease dementia from 1994 to 2012 in a population study Kumar B. Rajan, Jennifer Weuve,

Elevated DNA methylation across a 48-kb region spanning the HOXA gene cluster is associated with Alzheimer's disease neuropathology Rebecca G. Smith,

Molecular Analysis of a Deletion Hotspot in the NRXN1 Region Reveals the Involvement of Short Inverted Repeats in Deletion CNVs Xiaoli Chen, Yiping Shen,

LIFESPAN OF ONE FOCUSED ULTRASOUND MEDIATED BLOOD-BRAIN BARRIER TREATMENT IN A MOUSE MODEL OF ALZHEIMER'S DISEASE Charissa Poon, Kullervo Hynynen Alzheimer's.

Summary of the evidence on modifiable risk factors for cognitive decline and dementia: A population-based perspective Matthew Baumgart, Heather M. Snyder,

A Second Recombination Hotspot Associated with SHOX Deletions

Shruti Mishra, Brian Andrew Gordon, Karl A

Comparison of visual and quantitative florbetapir-PET reads in subjects with early Alzheimer's disease for assessing amyloid burden Bradley Wyman, Yahong.

A biomarker signal: Context-dependent hippocampal fMRI connectivity analysis of clinical trial measures in Alzheimer's disease Donald McLaren, Reisa.

The incremental diagnostic value of 18F-florbetapir imaging in naturalistic patients with cognitive impairment: The India-FBP study Marina Boccardi,

Practice Notes from the AAAI

Added value of 11C-PiB-PET imaging in the diagnosis of Alzheimer's disease Kristian Frederiksen, Anne-Mette Hejl, Ian Law, Steen Hasselbalch, Gunhild.

Mark D. Meadowcroft, Douglas G. Peters, Carson J

COGNITIVE COMPLAINTS IN OLDER ADULTS AT RISK FOR ALZHEIMER’S DISEASE ARE ASSOCIATED WITH ALTERED RESTING STATE NETWORKS Joey A. Contreras, Joaquín Goñi,

Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Distinct [18F]AV1451 retention patterns in clinical variants of Alzheimer’s disease Rik Ossenkoppele, Daniel Schonhaut, Suzanne Baker, Andreas Lazaris,

MR-less cortical surface-projection of PET images from 11C- and 18F-labeled radiotracers Vincent Doré, Pierrick Bourgeat, Luping Zhou, Jurgen Fripp,

Alzheimer's & Dementia: The Journal of the Alzheimer's Association

GREY MATTER CONNECTIVITY IS ASSOCIATED WITH CLINICAL PROGRESSION IN NON-DEMENTED, AMYLOID POSITIVE PATIENTS Betty M. Tijms, Mara ten Kate, Sander C.J.

Alzheimer's Association towards Guidelines for Dementia Care Practice: Recommendations with emphasis on high-quality, person-centered care in long-term.

Brain amyloid deposition and metabolism in early and late mild cognitive impairment Jared Rowley, Liyong Wu, Sara Mohades, Marina Dauar, Antoine Leuzy,

Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Genome-wide linkage analyses of non-Hispanic white families identify novel loci for familial late-onset Alzheimer's disease Brian W. Kunkle, James Jaworski,

INTRINSIC CONNECTIVITY NETWORKS IN POSTERIOR CORTICAL ATROPHY: A ROLE FOR THE PULVINAR? Carolyn A. Fredericks, Jesse Brown, Jersey Deng, Rik Ossenkoppele,

Extracting white matter hyperintensities in Alzheimer's disease risk and aging studies using supervised segmentation methods Vamsi Ithapu, Vikas Singh,

BRAIN AMYLOIDOSIS AND COGNITIVE DECLINE IN MCI: 12-MONTH FOLLOW-UP

Michael Navitsky, Abhinay D. Joshi, Michael D. Devous, Michael J

ONE-YEAR GLOBAL OUTCOME OF A COMPREHENSIVE, INDIVIDUALIZED, PERSON CENTERED MANAGEMENT (CI-PCM) PROGRAM + MEMANTINE IN ADVANCED AD: A RANDOMIZED CONTROLLED.

Bistra Iordanova, Matthew C. Murphy, William E. Klunk, Alberto L

Development of a Novel Next-Generation Sequencing Assay for Carrier Screening in Old Order Amish and Mennonite Populations of Pennsylvania Erin L. Crowgey,

Presentation transcript:

Replication and meta-analysis of the CHRFAM7A copy number variant in a cohort of clinically characterized and neuropathologically verified individuals Shanker Swaminathan, Matthew Huentelman, Jason Corneveaux, Amanda Myers, Kelley Faber, Tatiana Foroud, Richard Mayeux, Li Shen, Sungeun Kim, Mari Turk, John Hardy, Eric Reiman, Andrew Saykin Alzheimer's & Dementia: The Journal of the Alzheimer's Association Volume 8, Issue 4, Pages P40-P41 (July 2012) DOI: 10.1016/j.jalz.2012.05.101 Copyright © 2012 Terms and Conditions

Figure 1 Representative UCSC Genome Brower (March 2006) (NCBI36/hg 18) assembly) plots of CNV calls overlapping the CHRFAM7A (a) and APP (b) genes. Deletions are represented by red rectangles and duplications are represented by blue rectangles. Alzheimer's & Dementia: The Journal of the Alzheimer's Association 2012 8, P40-P41DOI: (10.1016/j.jalz.2012.05.101) Copyright © 2012 Terms and Conditions