Figure 5. Effect of insulin-like growth factor 1 (IGF-1) induced extracellular regulated protein kinases 1/2 (ERK1/2) activation and the signal-responsive.

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Figure 5. Effect of insulin-like growth factor 1 (IGF-1) induced extracellular regulated protein kinases 1/2 (ERK1/2) activation and the signal-responsive interaction of chloride channel-3 (CIC-3) with insulin-like growth factor receptor (IGF-R). (A) Effects of ClC-3 knockdown on the expression of ERK1/2 and phosphorylated ERK1/2 (pERK1/2). Bars represent mean±SD (n=5). Analysis of variance was employed for comparison. (B) Co-immunoprecipitation assay of ClC-3/IGF-R interaction in MDA-MB-231 cells (n=5). Cells were treated with or without IGF-1 (100 ng/mL). Protein extracts were immunoprecipitated (IP) with anti-IGF-R or anti-ClC-3 antibody, followed by immunoblotting (IB) with anti-IGF-R or anti-ClC-3.siRNA=small interfering RNA. *p<0.01 vs. control; †p<0.01 vs. IGF-1+Neg ClC-3. Figure 5. Effect of insulin-like growth factor 1 (IGF-1) induced extracellular regulated protein kinases 1/2 (ERK1/2) activation and the signal-responsive interaction of chloride channel-3 (CIC-3) with insulin-like growth factor receptor (IGF-R). (A) Effects of ClC-3 knockdown on the expression of ERK1/2 and phosphorylated ERK1/2 (pERK1/2). Bars… J Breast Cancer. 2018 Jun;21(2):103-111. https://doi.org/10.4048/jbc.2018.21.2.103