Jens U. Ponikau, MD, David A. Sherris, MD, Hirohito Kita, MD, Eugene B

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Presentation transcript:

Intranasal antifungal treatment in 51 patients with chronic rhinosinusitis Jens U. Ponikau, MD, David A. Sherris, MD, Hirohito Kita, MD, Eugene B. Kern, MD Journal of Allergy and Clinical Immunology Volume 110, Issue 6, Pages 862-866 (December 2002) DOI: 10.1067/mai.2002.130051 Copyright © 2002 Mosby, Inc. Terms and Conditions

Fig. 1 Intranasal application of amphotericin B. Patients apply 20 mL of antifungal solution into each nostril using a bulb syringe. Arrow shows hand movement to accomplish successful application of the antifungal drug from medial (ethmoid) to lateral (maxillary) sinuses. Journal of Allergy and Clinical Immunology 2002 110, 862-866DOI: (10.1067/mai.2002.130051) Copyright © 2002 Mosby, Inc. Terms and Conditions

Fig. 2 Coronal CT scan of patient with CRS demonstrates inflammatory mucosal thickening partially occluding the nasal cavity and paranasal sinuses before (left) and after (right) 4 months of intranasal treatment with amphotericin B. Journal of Allergy and Clinical Immunology 2002 110, 862-866DOI: (10.1067/mai.2002.130051) Copyright © 2002 Mosby, Inc. Terms and Conditions

Fig. 3 Summary of CT scans before and after intranasal amphotericin B treatment (n = 13). The figures show the percentage of inflammatory mucosal thickening occluding the nasal cavities and paranasal sinuses in patients with CRS before and after amphotericin B treatment. Each dot represents 1 patient, and the results of the same patients are connected by straight lines. Alternatively, the numbers of patients are indicated in parentheses above the straight lines. Open squares and error bars show means ± SEMs from 13 patients (3 patients had frontal and 6 patients had sphenoid disease). Journal of Allergy and Clinical Immunology 2002 110, 862-866DOI: (10.1067/mai.2002.130051) Copyright © 2002 Mosby, Inc. Terms and Conditions