Role of neurokinin 3 receptors on responses to colorectal distention in the rat: Electrophysiological and behavioral studies  Véronique Julia*, Xin Su*, Lionel Buéno‡, G.F. Gebhart*  Gastroenterology  Volume 116, Issue 5, Pages 1124-1131 (May 1999) DOI: 10.1016/S0016-5085(99)70015-6 Copyright © 1999 American Gastroenterological Association Terms and Conditions

Fig. 1 Effect of IP infusion of senktide (5 μg · kg−1 · 30 min−1) on (A) colonic motility and (B) abdominal contractions produced by CRD. Data are presented as the mean change in the number of spike bursts in response to CRD after drug administration. *Significantly different from corresponding control (0.0 mL; n = 8). Gastroenterology 1999 116, 1124-1131DOI: (10.1016/S0016-5085(99)70015-6) Copyright © 1999 American Gastroenterological Association Terms and Conditions

Fig. 1 Effect of IP infusion of senktide (5 μg · kg−1 · 30 min−1) on (A) colonic motility and (B) abdominal contractions produced by CRD. Data are presented as the mean change in the number of spike bursts in response to CRD after drug administration. *Significantly different from corresponding control (0.0 mL; n = 8). Gastroenterology 1999 116, 1124-1131DOI: (10.1016/S0016-5085(99)70015-6) Copyright © 1999 American Gastroenterological Association Terms and Conditions

Fig. 2 Effect of IP administration of SR 142,801 (1 mg/kg) on (A) colonic motility and (B) abdominal contractions produced by CRD. Data are presented as the mean change in the number of spike bursts in response to CRD after drug administration. *Significantly different from corresponding control (0.0 mL; n = 8). Gastroenterology 1999 116, 1124-1131DOI: (10.1016/S0016-5085(99)70015-6) Copyright © 1999 American Gastroenterological Association Terms and Conditions

Fig. 2 Effect of IP administration of SR 142,801 (1 mg/kg) on (A) colonic motility and (B) abdominal contractions produced by CRD. Data are presented as the mean change in the number of spike bursts in response to CRD after drug administration. *Significantly different from corresponding control (0.0 mL; n = 8). Gastroenterology 1999 116, 1124-1131DOI: (10.1016/S0016-5085(99)70015-6) Copyright © 1999 American Gastroenterological Association Terms and Conditions

Fig. 3 Effect of (A) IP administration of SR 142,801 (3 mg/kg) and (B) ICV administration of senktide (0.5 μg/kg) on the number of colonic spike bursts. Gastroenterology 1999 116, 1124-1131DOI: (10.1016/S0016-5085(99)70015-6) Copyright © 1999 American Gastroenterological Association Terms and Conditions

Fig. 4 Effect of ICV administration of senktide (0.05 μg/kg) on (A) colonic motility and (B) abdominal contractions produced by CRD. Data are presented as the mean change in the number of spike bursts in response to CRD after drug administration. *Significantly different from corresponding control (0.0 mL; n = 8). Gastroenterology 1999 116, 1124-1131DOI: (10.1016/S0016-5085(99)70015-6) Copyright © 1999 American Gastroenterological Association Terms and Conditions

Fig. 4 Effect of ICV administration of senktide (0.05 μg/kg) on (A) colonic motility and (B) abdominal contractions produced by CRD. Data are presented as the mean change in the number of spike bursts in response to CRD after drug administration. *Significantly different from corresponding control (0.0 mL; n = 8). Gastroenterology 1999 116, 1124-1131DOI: (10.1016/S0016-5085(99)70015-6) Copyright © 1999 American Gastroenterological Association Terms and Conditions

Fig. 5 Effect of ICV administration of SR 142,801 (0.1 mg/kg) on (A) colonic motility and (B) abdominal contractions produced by CRD. Data are presented as the mean change in the number of spike bursts in response to CRD after drug administration. *Significantly different from corresponding control (0.0 mL; n = 8). Gastroenterology 1999 116, 1124-1131DOI: (10.1016/S0016-5085(99)70015-6) Copyright © 1999 American Gastroenterological Association Terms and Conditions

Fig. 5 Effect of ICV administration of SR 142,801 (0.1 mg/kg) on (A) colonic motility and (B) abdominal contractions produced by CRD. Data are presented as the mean change in the number of spike bursts in response to CRD after drug administration. *Significantly different from corresponding control (0.0 mL; n = 8). Gastroenterology 1999 116, 1124-1131DOI: (10.1016/S0016-5085(99)70015-6) Copyright © 1999 American Gastroenterological Association Terms and Conditions

Fig. 6 Effect of intra-arterial administration of SR 142,801 on pelvic nerve afferent fibers innervating the colon in response to CRD. SR 142,801 was given by cumulative doses (1, 1 + 2, and 1 + 2 + 2 mg/kg) 5 minutes before the stimulus response function. Gastroenterology 1999 116, 1124-1131DOI: (10.1016/S0016-5085(99)70015-6) Copyright © 1999 American Gastroenterological Association Terms and Conditions

Fig. 7 Effect of intra-arterial administration of SR 142,801 on pelvic nerve afferent fibers innervating the urinary bladder in response to UBD. SR 142,801 was given by cumulative doses (1, 1 + 2, and 1 + 2 + 2 mg/kg) 5 minutes before the stimulus response function. Gastroenterology 1999 116, 1124-1131DOI: (10.1016/S0016-5085(99)70015-6) Copyright © 1999 American Gastroenterological Association Terms and Conditions