Milrinone Improves Pulmonary Hemodynamics and Right Ventricular Function in Chronic Pulmonary Hypertension Edward P Chen, Hartmuth B Bittner, R.Duane.

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Milrinone Improves Pulmonary Hemodynamics and Right Ventricular Function in Chronic Pulmonary Hypertension Edward P Chen, Hartmuth B Bittner, R.Duane Davis, Peter Van Trigt The Annals of Thoracic Surgery Volume 63, Issue 3, Pages 814-821 (March 1997) DOI: 10.1016/S0003-4975(97)00011-8 Copyright © 1997 The Society of Thoracic Surgeons Terms and Conditions

Fig. 1 Effects of intravenous milrinone on mean pulmonary artery pressure (mPAP) in the setting of monocrotaline pyrrole–induced chronic pulmonary hypertension. Six weeks after monocrotaline pyrrole injection, slight decreases in the mean pulmonary artery pressure were observed after milrinone administration at both 0.5 and 1.0 μg · kg−1 · min−1 compared with 0 μg · kg−1 · min−1, which were not statistically significant. The Annals of Thoracic Surgery 1997 63, 814-821DOI: (10.1016/S0003-4975(97)00011-8) Copyright © 1997 The Society of Thoracic Surgeons Terms and Conditions

Fig. 2 Effects of intravenous milrinone on pulmonary vascular resistance (PVR) in the setting of monocrotaline pyrrole–induced chronic pulmonary hypertension. Six weeks after monocrotaline pyrrole injection, significant decreases in the PVR were observed after milrinone administration at 0.5 and 1.0 μg · kg−1 · min−1 as compared with 0 μg · kg−1 · min−1. There was no further significant decrease in the PVR at 1.0 μg · kg−1 · min−1 as compared with 0.5 μg · kg−1 · min−1. (∗p < 0.05 versus 0 μg · kg−1 · min−1.) The Annals of Thoracic Surgery 1997 63, 814-821DOI: (10.1016/S0003-4975(97)00011-8) Copyright © 1997 The Society of Thoracic Surgeons Terms and Conditions

Fig. 3 Effects of intravenous milrinone on the pulmonary vascular impedance spectrum in the setting of monocrotaline pyrrole–induced chronic pulmonary hypertension. Six weeks after monocrotaline pyrrole injection, there was a significant decrease in the input resistance (RIN) after milrinone infusion at both 0.5 and 1.0 μg · kg−1 · min−1 as compared with 0 μg · kg−1 · min−1. However, there was no further significant decrease in the RIN at 0.5 μg · kg−1 · min−1 as compared with 1.0 μg · kg−1 · min−1. No significant differences in the characteristic impedance (Z0) occurred after milrinone infusion compared with 0 μg · kg−1 · min−1. (∗p < 0.05 versus 0 μg · kg−1 · min−1.) The Annals of Thoracic Surgery 1997 63, 814-821DOI: (10.1016/S0003-4975(97)00011-8) Copyright © 1997 The Society of Thoracic Surgeons Terms and Conditions

Fig. 4 Effects of intravenous milrinone on right ventricular myocardial performance, as measured by right ventricular preload recruitable stroke work (RV PRSW), in the setting of monocrotaline pyrrole–induced chronic pulmonary hypertension. Milrinone infusion led to significant increases in the RV PRSW at 1.0 μg · kg−1 · min−1 as compared with 0 μg · kg−1 · min−1. The RV PRSW at an infusion rate of 0.5 μg · kg−1 · min−1 was also increased compared with 0 μg · kg−1 · min−1; however, this difference did not reach statistical significance. (∗p < 0.05 versus 0 μg · kg−1 · min−1.) The Annals of Thoracic Surgery 1997 63, 814-821DOI: (10.1016/S0003-4975(97)00011-8) Copyright © 1997 The Society of Thoracic Surgeons Terms and Conditions