A single administration of MPD increases theVmax of vesicular [3H]DA uptake. A single administration of MPD increases theVmax of vesicular [3H]DA uptake.

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A single administration of MPD increases theVmax of vesicular [3H]DA uptake. A single administration of MPD increases theVmax of vesicular [3H]DA uptake. Rats received a single administration of MPD (40 mg/kg, s.c.) or saline vehicle (1 ml/kg, s.c.) and were killed 1 hr later. The Eadie–Hofstee plot depicts data from one of four experiments, with samples in each run in duplicate. The mean Km values were 235 ± 27 and 230 ± 10 nm for saline- and MPD-treated rats, respectively. The mean Vmax values for all four experiments combined were 1584 ± 129 and 2350 ± 250 fmol/μg protein for 3 min for saline- and MPD-treated rats, respectively; these values differed significantly (p ≤ 0.05). Verónica Sandoval et al. J. Neurosci. 2002;22:8705-8710 ©2002 by Society for Neuroscience