Figure 4. Effects of chloride channel-3 (ClC-3) knockdown on the expression of cell cycle-regulatory proteins. (A) Representative western blot images of Ki-67, proliferating cell nuclear antigen (PCNA), cyclins, and p21. (B) Densitometric analysis of the effects of ClC-3 knockdown on expression of Ki-67, PCNA, cyclin D1, cyclin E, and p21 (n=5).GAPDH=glyceraldehyde 3-phosphate dehydrogenase; IGF-1=insulin-like growth factor 1; siRNA=small interfering RNA. *p<0.01 vs. control; †p<0.01 vs. IGF-1. Figure 4. Effects of chloride channel-3 (ClC-3) knockdown on the expression of cell cycle-regulatory proteins. (A) Representative western blot images of Ki-67, proliferating cell nuclear antigen (PCNA), cyclins, and p21. (B) Densitometric analysis of the effects of ClC-3 knockdown on expression of Ki-67, PCNA, cyclin D1, cyclin E, and… J Breast Cancer. 2018 Jun;21(2):103-111. https://doi.org/10.4048/jbc.2018.21.2.103