Cyclin D2 protein is expressed in the developing human cortex

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Cyclin D2 in the basal process of neural progenitors is linked to non‐equivalent cell fates Cyclin D2 protein is expressed in the developing human cortex. (A–E”) At 16 GW, Cyclin D2 is expressed at three principal locations: the basal aspects of the CP near the MZ (box C); the subplate (box D), and the apical aspects of the VZ (box E). At higher magnification, Cyclin D2 in the basal aspects and the subplate are present in a punctate fashion along the cellular processes and not in the cell nuclei stained with DAPI (C, D). In the VZ, Cyclin D2 staining colocalizes with nuclei of neural progenitor cells (E). (F–H) Localization of Cyclin D2 protein in SP and OSVZ regions of the 19 GW human cortex showing Cyclin D2 staining in cells and also in a long basal process (F and H; arrows in insets). MZ, marginal zone; CP, cortical plate; SP, subplate; OSVZ, outer subventricular zone; VZ/ISVZ, ventricular zone/inner subventricular zone. Scale bars: 100 μm in (A and B), 25 μm in (C–E”), and 50 μm in (F–H). IF THIS IMAGE HAS BEEN PROVIDED BY OR IS OWNED BY A THIRD PARTY, AS INDICATED IN THE CAPTION LINE, THEN FURTHER PERMISSION MAY BE NEEDED BEFORE ANY FURTHER USE. PLEASE CONTACT WILEY'S PERMISSIONS DEPARTMENT ON PERMISSIONS@WILEY.COM OR USE THE RIGHTSLINK SERVICE BY CLICKING ON THE 'REQUEST PERMISSIONS' LINK ACCOMPANYING THIS ARTICLE. WILEY OR AUTHOR OWNED IMAGES MAY BE USED FOR NON-COMMERCIAL PURPOSES, SUBJECT TO PROPER CITATION OF THE ARTICLE, AUTHOR, AND PUBLISHER. EMBO J, Volume: 31, Issue: 8, Pages: 1879-1892, First published: 06 March 2012, DOI: (10.1038/emboj.2012.43)