A, rate of proliferation of PC3 prostate cancer cells is greatly reduced by treatment with oligomers containing CpG motifs, as assessed by (a) soft agar.

Slides:

Advertisements

Similar presentations

Figure 1. Identification of the most-abundant phytochemicals in GLE

Advertisements

Strategies for differential inhibition of mTORC1 and mTORC2 with rapamycin. Strategies for differential inhibition of mTORC1 and mTORC2 with rapamycin.

SCLCs and LCNECs are sensitive to PARP inhibition in vitro.

NF1 silencing confers resistance of PC9 lung adenocarcinoma cells to erlotinib (erl). NF1 silencing confers resistance of PC9 lung adenocarcinoma cells.

Cellular activity and selectivity of ARS-853.

NF1 downregulation activates MAPK pathway signaling.

Interfering with HMGA2 expression blocks transformation in metastatic lung cancer cells. Interfering with HMGA2 expression blocks transformation in metastatic.

The average median S.D. and PEV reduction after applying different normalization methods compared with raw data. The average median S.D. and PEV reduction.

Fig. 4 ALRN-6924 inhibits cellular proliferation and clonogenic capacity, and induces cell cycle arrest and apoptosis in AML cell lines. ALRN-6924 inhibits.

TDP1 knockdown increases the sensitivity of rhabdomyosarcoma cell lines to CPT treatment. TDP1 knockdown increases the sensitivity of rhabdomyosarcoma.

Lapatinib reduces IGF-I signaling in trastuzumab-resistant cells.

A, IC50 dose–response curves of SYD985, T-DM1, and ADC isotype control in all USC cell lines tested in vitro (i.e., HER2 3+ cell lines, P =

Immunohistochemical detection of 8-OHdG by use of the 1F7 monoclonal antibody in oligomer-treated PC3 prostate cancer cells. a, control untreated peripheral.

Representative Western blot analyses of S-phase and other proteins from PC3 cell lysates obtained 3 days after oligomer (400 nm)/Lipofectin (15 μg/ml)

Change in antibody-dependent cellular cytotoxicity between baseline and day 15, day 30, and day 45 for cohort 1 and 2 versus cohort 3. Change in antibody-dependent.

Protracted temozolomide (TMZ) treatment leads to acquired TMZ resistance in glioblastoma (GBM) cells in vivo. Protracted temozolomide (TMZ) treatment leads.

A, ATP production by PC3 prostate cancer cells after treatment with oligonucleotide/Lipofectin complexes. a, ATP production by PC3 prostate cancer cells.

Effect of HA on hematopoietic recovery in tumor-bearing mice.

A, cytotoxicity induced on HER2 3+ USC (ARK-2), HER2 0/1+ USC (ARK-4), and ARK-2/ARK-4 cocultures with 1 μg/mL of SYD985, T-DM1, and ADC isotype control.

Silencing hOGG1 triggers caspase-3 and caspase-7 activation in response to H2O2 in GM00637 cells. Silencing hOGG1 triggers caspase-3 and caspase-7 activation.

G3139 substitutes for heparin, which is required for the biological activity of FGF2. G3139 substitutes for heparin, which is required for the biological.

Combination effect of AdTOP-PUMA and chemotherapeutic agents in colon cancer cells. Combination effect of AdTOP-PUMA and chemotherapeutic agents in colon.

Suppression of melanoma cell proliferation in response to kinase inhibitors. Suppression of melanoma cell proliferation in response to kinase inhibitors.

CDDO-Me induces apoptosis independent of Bcl-2 level as well as p53 status in human NSCLC cells. CDDO-Me induces apoptosis independent of Bcl-2 level as.

Effects of WDL on in vitro invasion and soft agar colony formation by LNCaP cells. Effects of WDL on in vitro invasion and soft agar colony formation by.

Overexpression of miR-335, but not miR-29a, reduces in vitro carcinogenesis. Overexpression of miR-335, but not miR-29a, reduces in vitro carcinogenesis.

Induction of cell death in prostate cancer cells by SAHA and ZOL

Drug sensitivities of IGROV1 cells to AGF94 and PMX at leucovorin (LCV) concentrations of 2 and 25 nmol/L. Drug sensitivities of IGROV1 cells to AGF94.

IL-13Rα2 promotes cell survival and proliferation.

The effect of IAA and glycyrrhizin (Gc) on growth of human melanoma cells. The effect of IAA and glycyrrhizin (Gc) on growth of human melanoma cells. A,

Specific cytotoxicity of DTEGF13.

Knockdown of PKM2 suppressed TPA-induced skin cell transformation.

Biological effects of BRAF silencing: growth curves of A375 (A) and ARO (B) cell lines in the absence or presence of doxycycline. Biological effects of.

Positions of the EGFR exon 20 insertions identified over a 3-year period and comparison with the spectrum of EGFR exon 19 and HER2 insertion mutations.

Effect of IL24 on phosphorylation of eIF2α and proliferation in cancer cells. Effect of IL24 on phosphorylation of eIF2α and proliferation in cancer cells.

Src expression in a panel of human TCC cell lines.

Antitumor effects of celastrol in vitro and in vivo.

Cocultivation of fibroblasts with epithelial cells (EP156T-luc).

Colony formation of K-562 cells after 24 h (upper panel) or 48 h (lower panel) exposure to ErPC3 (20 μm) and ASO-bcr (10 μm), respectively. Colony formation.

Effect of miRNA mimic on platinum sensitivity.

Targeting HR via CDK inhibition resensitizes recurrent cultures to temozolomide (TMZ). Targeting HR via CDK inhibition resensitizes recurrent cultures.

Binding and antiproliferative effects of ANG4043 and anti-HER2 mAbs on tumor cells. Binding and antiproliferative effects of ANG4043 and anti-HER2 mAbs.

Xenograft regrowth studies.

CDCP1 links Ras and SFK signaling and regulates anoikis resistance, cell migration, and invasion in NSCLC cells. CDCP1 links Ras and SFK signaling and.

FACS analyses of the inhibitory effect induced by mixed docetaxel, gefitinib, and cyclopamine on EGF plus SHHNp–stimulated PC3 cells. FACS analyses of.

Inhibitory effect of SFN pretreatment on the TPA-induced transformation of shMock- and shNrf2-transfected JB6 P+ cells. Inhibitory effect of SFN pretreatment.

Inhibitory effects of SFN on the TPA-induced transformation of JB6 P+ cells. Inhibitory effects of SFN on the TPA-induced transformation of JB6 P+ cells.

Endogenously produced n-3 PUFAs inhibit endometrial cancer cell growth in vitro and in vivo. Endogenously produced n-3 PUFAs inhibit endometrial cancer.

Flow cytometric analysis of ROS production in oligonucleotide-treated PC3 prostate cancer cells as demonstrated by the oxidation of H2DCF → DCF and HE.

Per1 inhibits growth and induces apoptosis in prostate cancer cell lines. Per1 inhibits growth and induces apoptosis in prostate cancer cell lines. LNCaP,

The effect of different concentrations of WMC-79 and time of exposure on the growth of HCT-116 cells. The effect of different concentrations of WMC-79.

Drug interaction signatures for GIST and benign osteoma cell lines representing all combinatorial data compiled in a 9 × 9 drug matrix. Drug interaction.

Ki-67 expression in M31- and H3-treated tumors (A) and respective Ki-67 labeling indices in the two groups of tumors (B). Ki-67 expression in M31- and.

Effects of EGCG on the anchorage-independent growth of EFT cells.

Effect of the crystal form and solid dispersion preparations of KRN633 on the growth of human tumor xenografts in mice. Effect of the crystal form and.

miR-100 suppresses bladder cancer cell growth in vitro and in vivo.

CRA inhibits the growth of human tumor xenografts in vivo.

Changes in signal transduction pathway induced by gefitinib.

FBXL19-AS1 knockdown inhibits proliferation, migration and invasion, and reduces the expression levels of angiogenesis related proteins in lung cancer.

VEGF165 stimulates migration of HMVECs

AR inhibition decreases ER+/AR+ breast cancer growth.

Effects of ASGR2 knockdown on the phenotypes of MKN1 cells.

A, cell number was assessed 96 hours after exposure to indicated treatment in indicated cell models. A, cell number was assessed 96 hours after exposure.

A, DMA and Ral significantly inhibit estrone methyl ether (MeOE1) formation in MCF-10A cells. A, DMA and Ral significantly inhibit estrone methyl ether.

Proliferation of TA3-Ha and TA3-St cells in vitro and in vivo.

AXL overexpression decreases proliferation in vitro.

Depleting NQO1 expression levels inhibits growth of NSCLC cells in soft agar. Depleting NQO1 expression levels inhibits growth of NSCLC cells in soft agar.

BME treatment increases cytotoxic activity of NK3

AXL knockout does not prevent dormancy.

DHA and dietary n-3 PUFAs inhibit endometrial cancer cell growth in vitro and in xenograft models. DHA and dietary n-3 PUFAs inhibit endometrial cancer.

Presentation transcript:

a, rate of proliferation of PC3 prostate cancer cells is greatly reduced by treatment with oligomers containing CpG motifs, as assessed by (a) soft agar colony formation assay and (b and c) trypan blue exclusion. a, rate of proliferation of PC3 prostate cancer cells is greatly reduced by treatment with oligomers containing CpG motifs, as assessed by (a) soft agar colony formation assay and (b and c) trypan blue exclusion. G3139 and 2006 caused a dramatic inhibition in cloning efficiency and cellular proliferation after 6 days (a and b). b, G4126 and G4232 only slightly affected the proliferation rate, whereas the effect of 2009, a two-base longer oligomer, is intermediate. c, 84825 (C5 methylation outside the CpGs) inhibited cell proliferation to the same extent as G3139. However, oligonucleotides with only a single C5-methylated CpG (84822 and 84823) considerably lessen the inhibitory effect on cell proliferation. Lines, average; bars, SD (n = 3). *, P < 0.05, by Student's t test assuming unequal variances. (Control not included in analysis: All comparisons made to G4126 to eliminate nonspecific oligonucleotide treatment.)‏ Jonathan C. Lai et al. Mol Cancer Ther 2003;2:1031-1043 ©2003 by American Association for Cancer Research