Enrichment of mononucleosomes and oligonucleosomes in the cytoplasmic fraction after a 6.25 mm injury (enrichment factor, absorbance of the injured tissue/absorbance.

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Presentation transcript:

Enrichment of mononucleosomes and oligonucleosomes in the cytoplasmic fraction after a 6.25 mm injury (enrichment factor, absorbance of the injured tissue/absorbance of the normal control tissue). Enrichment of mononucleosomes and oligonucleosomes in the cytoplasmic fraction after a 6.25 mm injury (enrichment factor, absorbance of the injured tissue/absorbance of the normal control tissue). An ELISA kit (see Materials and Methods) was used to detect mononucleosomes and oligonucleosomes in the cytoplasmic fraction of spinal cord tissue at the indicated times after injury. Evidence of internucleosomal DNA fragmentation peaked 24 hr after injury and was reduced by cycloheximide treatment. Error bars indicate SEM; *p < 0.05; n = 3 animals per group. Xiao Z. Liu et al. J. Neurosci. 1997;17:5395-5406 ©1997 by Society for Neuroscience