The pulmonary microbiome of children with persistent bacterial bronchitis (PBB). The pulmonary microbiome of children with persistent bacterial bronchitis.

Slides:



Advertisements
Similar presentations
Effects of a caspase-1 inhibitor and NLRP3 inhibitor on nontypeable Haemophilus influenzae (NTHi)-induced interleukin (IL)-1β production. a) Peripheral.
Advertisements

The 20-year overall survival was significantly higher in the newborn screening (NBS) group than in the symptoms group for each of the subgroups defined.
The influence of noninvasive ventilation (NIV) on the delicate balance between increased load and decreased capacity of the respiratory system in severe.
Ventilatory and cerebrovascular responses to hyperoxic hypercapnia.
Microbiomic changes during inhaled interferon (IFN)-γ
Kaplan–Meier curves of 12-month survival after an index chronic obstructive pulmonary disease-related hospitalisation according to level of moderate and.
Relationship between the change in a) ventilatory and b) cerebrovascular responses in older healthy subjects (Older) and chronic obstructive pulmonary.
Dried blood spot for therapeutic drug monitoring. a).
Prevalence of true-positive, false-negative and false-positive cases of chronic obstructive pulmonary disease identified with the fixed-limit Global Initiative.
Composition of microbial communities in induced sputa of healthy and mild, moderate, severe or very severe (end-stage) lung disease affected individuals.
Forced expiratory volume in 1 s (FEV1) results in the RECOVER trial.
A) CT scan of patient number 1, before pembrolizumab; b) CT scan of patient number 1, after 11 pembrolizumab infusions; c) CT scan of patient number 1,
Survival without tracheostomy
The correlation between Mycobacterium growth indicator tube (MGIT) time to culture positivity (TTP) and bacterial load count by molecular bacterial load.
Influence of do-not-resuscitate (DNR) order specification on overall survival in chronic obstructive pulmonary disease (COPD) patients (log rank test p
Kaplan–Meier curve for the time until the development of lung cancer in patients with idiopathic pulmonary fibrosis. Kaplan–Meier curve for the time until.
Distribution of lower extremity artery disease (LEAD) Fontaine stages over the combined chronic obstructive pulmonary disease (COPD) Global Initiative.
MRNA expression of collagen-binding integrins in idiopathic pulmonary fibrosis (IPF) lungs. mRNA expression of collagen-binding integrins in idiopathic.
Comparative expression of discoidin domain receptors (DDRs) between healthy lung tissues and those from different types of interstitial lung disease (ILD):
Bland–Altman comparison of lung clearance index (LCI) from multiple breath wash-out following open and modified closed circuit wash-in for both healthy.
Venn diagram showing the overlap between the various chronic obstructive pulmonary disease (COPD) diagnoses: self-reported physician-diagnosed, fixed ratio.
Kaplan–Meier survival curves of all-cause mortality in patients with idiopathic pulmonary fibrosis (IPF). Kaplan–Meier survival curves of all-cause mortality.
Different lung function trajectories potentially relevant for the understanding of the natural history of chronic obstructive pulmonary disease. a) Lung.
A white elephant or the elephant in the room
Percentage of previously treated tuberculosis (TB) cases with multidrug-resistant (MDR)-TB. Percentage of previously treated tuberculosis (TB) cases with.
Risk of bias summary for Cochrane review comparing pMDI and spacer to nebulisers to deliver β2-agonists to adults and children with acute asthma. Risk.
Forest plot showing the number of adults (at the top) and children (lower down) who were admitted to hospital after treatment in the emergency department.
Change in lung clearance index (LCI) (mean±sd % change lung turnovers compared with baseline) based on modelled a, b) continuous and c, d) isolated pre-capillary.
Clonal strains of Pseudomonas aeruginosa were identified from independent patient-pairs using multilocus sequence typing (MLST). Clonal strains of Pseudomonas.
Representative diaphragm electromyogram (EMG) tracings at rest (a and b) and during maximum voluntary ventilation (c and d) in a healthy subject (a and.
Rhinovirus (RV) infection induces caspase-1 expression in bronchial epithelial cells in asthma. Rhinovirus (RV) infection induces caspase-1 expression.
Box-plot of alpha-diversity measured by wholetree phylogenetic differences grouped according to sampling method and chronic obstructive pulmonary disease.
Most frequent words and phrases based on user comments about the registry. Most frequent words and phrases based on user comments about the registry. Word.
A) Experimental system to carry out a bench test of noninvasive ventilators. a) Experimental system to carry out a bench test of noninvasive ventilators.
Phosphorylation levels of discoidin domain receptor (DDR)2.
Non-typeable Haemophilus influenzae (NTHi)-stimulated cytokine production. Non-typeable Haemophilus influenzae (NTHi)-stimulated cytokine production. Peripheral.
Prevalence of chronic bronchitis in relation to active smoking, stratified by age. □: nonsmokers; ▒: 1–10 cigarettes per day; ░: 11–20 cigarettes per day;
Systems biology as a tool to improve idiopathic pulmonary fibrosis (IPF) treatment effectiveness. Systems biology as a tool to improve idiopathic pulmonary.
a) Mortality per time point (p<0
Relationship between exercise mPAP and cardiac output.
Scatter plot of the % change versus baseline in pulmonary function test results at a) 4 months and b) the end of the study versus the analyte concentration.
3-year survival of lung cancer patients in the general population and in those with a prior diagnosis of chronic obstructive pulmonary disease (COPD).
A family-based pulmonary rehabilitation (PR) programme enhanced the coping resources of the families of chronic obstructive pulmonary disease patients.
A)Standardised mortality ratios for chronic bronchitis in men and women (1968–1978) and b) infant mortality from bronchitis and pneumonia per 1000 births.
Bacterial community comparison of samples with the most abundant bacterial families (>0.5% mean relative abundance). Bacterial community comparison of.
Forest plot of adjusted odds ratios (with 95% confidence intervals) from multivariable multinomial logistic regression analysis (table 4), by number of.
Incidence of chronic obstructive pulmonary disease according to the history of chronic cough/phlegm. Incidence of chronic obstructive pulmonary disease.
Severe exacerbations and emergency department (ED) visits in the 5 years after bronchial thermoplasty (BT). a) Proportion of subjects with severe exacerbations.
Proportion of patients in each World Health Organization functional class (WHO-FC) at the time of pulmonary arterial hypertension-associated systemic sclerosis.
Effects of interleukin-1 receptor antagonist (IL-1Ra) on peripheral blood mononuclear cell (PBMC) responses to non-typeable Haemophilus influenzae (NTHi).
Weekly pneumococcal community-acquired pneumonia incidence rates over 5 years, with delineated school holiday periods by year. a) Year 1 (September 2008–2009).
Differences in a) functional residual capacity (FRC) and b) lung clearance index (LCI) when using all trials in comparison with only the first two trials.
Scatter plot of body mass index (BMI) versus forced expiratory volume in the first second (FEV1), and linear correlation lines for normal spirometry and.
Exposure to intermittent hypoxia after 13 nights led to an increase in sympathetic activity measured by muscle sympathetic nerve activity (MSNA). Exposure.
Distribution of patients in the first- or second-year follow-up according to the number of acute exacerbations of chronic obstructive pulmonary disease.
Change in the regular use of inhaled corticosteroids (as a single inhaler or in combination; any use in the last 12 months) in participants with persistent.
Bland–Altman comparison of functional residual capacity (FRC) measured from multiple breath wash-out following open and modified closed circuit wash-in.
Effect of the presence of aetiological factors (bacterial or viral infection, or eosinophilic inflammation) at stable visits on the odds of experiencing.
Correlation between inspiratory capacity (IC)/total lung capacity (TLC) ratio and oxygen pulse at peak exercise in chronic obstructive pulmonary disease.
A) Micro-computed tomography data corresponding to a helium-3 magnetic resonance imaging voxel size of 7×7×7 mm and b) the segmented single acinus volume.
Usability statistics among active users of the national tuberculosis (TB) registry by TB burden. Usability statistics among active users of the national.
Expression of genes related to inflammasome activation in peripheral blood mononuclear cell (PBMC) and bronchoalveolar lavage (BAL) macrophages. Expression.
The European population from 1950 to 2050, with estimated population before 2006 (light background) and projected population (dark background). The European.
Bench test setting for automatic continuous positive airway pressure (APAP) devices. a) System to simulate the breathing pattern and airway obstructions.
Composition of the most common clusters at the a) onset of the first acute respiratory tract infection (swab A) and b) 3 weeks later (swab B) illustrated.
24-h blood pressure profile after a, d) one night of intermittent hypoxia (IH) exposure, b, e) 13 nights IH exposure and c, f) 5 days after cessation of.
Baseline New York Heart Association functional class (NYHA FC) predicts survival in patients with pulmonary hypertension using infused epoprostenol therapy.
The grading system illustrated by photographic images of the larynx showing the different grades of laryngeal obstruction at the glottic and supraglottic.
Percentage of positive results by pathogen among study patients with identified pathogens. “Other” includes respiratory viruses, Stenotrophomonas, Prevotella,
Effect of placebo (n=88) and bosentan (n=80) on the co-primary end-point pulmonary vascular resistance (PVR) in the EARLY (Endothelial Antagonist Trial.
Presentation transcript:

The pulmonary microbiome of children with persistent bacterial bronchitis (PBB). The pulmonary microbiome of children with persistent bacterial bronchitis (PBB). DNA was extracted from bronchial brushes of 24 PBB children and 18 healthy controls and 16S rRNA gene qPCR quantified the bacterial burden prior to sequencing. Permutational multivariate analysis of variance shows that total community dissimilarity is significantly different (R2=0.08, p=0.004) and indicator species analysis shows that Haemophilus is significantly associated with PBB. Reproduced from [1] with permission from the publisher. Jonathan Grigg et al. ERJ Open Res 2017;3:00127-2016 ©2017 by European Respiratory Society