BRCA1 promoter methylation detected in the peripheral blood and corresponding tumor. BRCA1 promoter methylation detected in the peripheral blood and corresponding.

Slides:



Advertisements
Similar presentations
Methylation of individual CpG sites within p16 CpG islands in various human gastric lesions Zheming Lu( 陆哲明) Dajun Deng (邓大君) Beijing University School.
Advertisements

Date of download: 9/19/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Germline Epigenetic Regulation of KILLIN in Cowden.
IDH1 mutant glioma cells are sensitive to TMZ
DNA damage foci in irradiated cells.
Anti–4-1BB/PD-1 combination enriched CD8+ T cells in TILs
Ken B. Waites, Li Xiao, Vanya Paralanov, Rose M. Viscardi, John I
Genomic DNA methylation (ng mCyt/μg DNA) according to combined MTHFR 1298A>C and 677C>T genotypes and low or high plasma folate levels (i.e., below or.
Dihydromyricetin decreases the sphere formation through downregulation of Sox2 in human osteosarcoma. Dihydromyricetin decreases the sphere formation through.
High-throughput analysis of informative CpG sites for the four studied tumor suppressor genes (A-D). High-throughput analysis of informative CpG sites.
Quantitative PCR of CRTAC1 (white columns) and WASF1 (black columns) loci in germ line DNA (A), glomus tumor no. 1 (B), and glomus tumor no. 3 (C) from.
Application of COLD-PCR for Improved Detection of NF2 Mosaic Mutations
ROC curve for separating advanced stages (advanced BE and EA) versus early stages (BE or BE instability) using total genome-wide LOH [area under the curve.
The human GPR109A promoter is methylated and GPR109A expression is silenced in human colon carcinoma cells. The human GPR109A promoter is methylated and.
Schematic depiction of CTC processing methods.
NICD1 immunohistochemical staining in normal and tumor tissue.
CAPP2: Time to first colorectal cancer in those randomized to aspirin compared with those randomized to the aspirin placebo. CAPP2: Time to first colorectal.
Fig. 1. Schematic showing the shedding of tumor DNA from head and neck cancers into the saliva or plasma. Schematic showing the shedding of tumor DNA from.
Changes in the ratio of (EPA+DHA):AA in the breast triacylglyceride compartment. Changes in the ratio of (EPA+DHA):AA in the breast triacylglyceride compartment.
A and B, mRNA expression for ZNF423 (A) and BRCA1 (B) for lymphoblastoid cell lines with WT/WT (8 cell lines), WT/V (7 cell lines), and V/V (8 cell lines)
The TSDR of ATL cells exhibits Treg-like hypomethylated status or CD4+ conventional T cell–like methylated status. The TSDR of ATL cells exhibits Treg-like.
Fig. 1. Detection of circulating tumor DNA in CRPC patients.
TFAP2A is highly expressed in nasopharyngeal carcinoma cells and tumor tissues. TFAP2A is highly expressed in nasopharyngeal carcinoma cells and tumor.
Induction of apoptosis by NS398.
Methylation status of IGFBPL1 in human breast cancer.
Effects of AG on the colon histology score in the acute DSS colitis model. Effects of AG on the colon histology score in the acute DSS colitis model. Ten.
Integrated mRNA and microRNA expression and DNA methylation clusters.
A, high-resolution methylation analysis of ZNF545 promoter by BGS in representative carcinoma cell lines. A, high-resolution methylation analysis of ZNF545.
Protein expression profile in a dasatinib-resistant cell line.
Effects of maternal exposure during pregnancy to tap water (control), LIM, or HIM on offspring tumor incidence (% rats with tumors; A), tumor multiplicity.
A, scatterplots of qMSP analysis of candidate genes promoters in the prevalence screen cohort, which consisted of 55 HNSCC tumor tissue samples and 37.
KIT mutations in GISTs. A, amino acid sequence of KIT exon 11 mutations in clinical GIST biopsies. –, amino acids that are deleted; italicized amino acids,
Correlation between serum visfatin concentrations and the clinical stage (A) and tumor size (B, C) of HCCs. A and B, the correlations were determined by.
The ITGAL promoter is methylated in fibroblasts but not T cells
The I1307K APC gene variant was identified using primers designed to detect the I1307K. The I1307K APC gene variant was identified using primers designed.
A, unsupervised clustering of all BRCA1 (red), BRCA2 (blue), and sporadic (green) breast tumors of our collection using the regions reported as discriminative.
A, Proportion of variants detected in the MMR genes.
Plasma and tissue EGFR allele analyses.
Positions of the EGFR exon 20 insertions identified over a 3-year period and comparison with the spectrum of EGFR exon 19 and HER2 insertion mutations.
Supernatants of the positive proliferative responses indicated in Table 1 were analyzed for the presence of IFNγ, tumor necrosis factor-α, IL-2, IL-4,
Validation of GHSR, SST, and ZIC1 in hrHPV-positive cervical scrapes and their relation to duration of lesion existence and DNA copy number aberrations.
Endogenously produced n-3 PUFAs inhibit endometrial cancer cell growth in vitro and in vivo. Endogenously produced n-3 PUFAs inhibit endometrial cancer.
Detection of PSA-mRNA by single (first panel, 710 bp) and nested (second panel, 455 bp) RT-PCR. Detection of PSA-mRNA by single (first panel, 710 bp) and.
Comparison of the frequency of nucleotide variation in the mtDNA D-loop region between stomach and other tumor cell lines. Comparison of the frequency.
Immunologic and pharmacokinetic studies.
Kaplan-Meier survival analysis of p53 mutation in the overall breast tumor series. Kaplan-Meier survival analysis of p53 mutation in the overall breast.
DNA demethylation reactivates GSN expression in gastric cancer cells.
Association between BRCA1 transcript level and cisplatin sensitivity, BRCA1 promoter methylation, and NtAI. Association between BRCA1 transcript level.
Number of identical D-loop DNA clones detected in 10 DNA clones derived from liver tumor tissues. Number of identical D-loop DNA clones detected in 10.
Representative photograph of somatic mutations detected by PCR-SSCP.
Methylation-specific PCR of APC, RASSF1A, and p14ARF genes in bladder tumor and urine DNAs. In the APC gel panel viewed from left to right, the first (TCC34)
Met is expressed in Her2-overexpressing cell lines and Her2 (+) breast tumors. Met is expressed in Her2-overexpressing cell lines and Her2 (+) breast tumors.
Representative images demonstrating LOH in breast cancer patients’ paired BM aspirate and primary tumors (T) at D14S62, D14S51, and D8S321, respectively.
qPCR system for the FOXP3 TSDR to detect Treg.
Increased apoptotic levels after combined treatment with vincristine (VCR) and imatinib. Increased apoptotic levels after combined treatment with vincristine.
Increased apoptotic levels after combined treatment with DXR and imatinib. Increased apoptotic levels after combined treatment with DXR and imatinib. A–D.
GATA-3 immunostaining was scored semiquantitatively; tumors with
Histology (H&E; original magnification, ×100 for B-2P/C-12P/C-64P and ×40 for C-10P; top) of small-sized lung adenocarcinomas and immunohistochemical staining.
End joining of BstXI substrates by PCO cultures.
A, DMA and Ral significantly inhibit estrone methyl ether (MeOE1) formation in MCF-10A cells. A, DMA and Ral significantly inhibit estrone methyl ether.
HOXA11-AS acts as a ceRNA for miR-1297.
Methylation targets of TET1 in vitro.
Representative biodistribution pattern of 111In-CMD-193.
A and B, linearity of the preamplification step shown by a similar expression pattern of ERα mRNA in four breast tumor samples pre– and post–linear amplification.
The pattern of association between all-cancer mortality risk and long-term exposure to PM2.5 (μg/m3). The pattern of association between all-cancer mortality.
Increased growth factor receptor expression in lungs and tumors of hypoxic mice. Increased growth factor receptor expression in lungs and tumors of hypoxic.
Detection of BRCA reversion mutations in pretreatment cfDNA and tumor biopsy. Detection of BRCA reversion mutations in pretreatment cfDNA and tumor biopsy.
Tobacco-specific carcinogens induce methylation, DNA adducts, DNA damage, and activation of DNMT1. Tobacco-specific carcinogens induce methylation, DNA.
MDSC population in patient peripheral blood.
I3C reduces the level of Cdc25A protein in breast cancer cells.
CONSORT diagram. a, 5 had a major treatment violation (3 refused and 2 received wrong treatment) but were included in the analyses; b, 4 had a major treatment.
Presentation transcript:

BRCA1 promoter methylation detected in the peripheral blood and corresponding tumor. BRCA1 promoter methylation detected in the peripheral blood and corresponding tumor. MS-HRM Tm curves are shown for the peripheral blood DNA (A) and corresponding tumor-enriched DNA (B) of individual P1.16. The DNA is shown compared with a set of dilution standards. The blood was analyzed using the 122 bp fragment whereas the tumor was analyzed using the 79 bp fragment. Forward sequences for the same individual are shown for a methylated clone from the peripheral blood DNA (C) and corresponding tumor-enriched DNA (D). Ee Ming Wong et al. Cancer Prev Res 2011;4:23-33 ©2011 by American Association for Cancer Research