Two Tales (Tails) of SAMHD1 Destruction by Vpx

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Two Tales (Tails) of SAMHD1 Destruction by Vpx Xiaoyun Ji, Yong Xiong Cell Host & Microbe Volume 17, Issue 4, Pages 425-427 (April 2015) DOI: 10.1016/j.chom.2015.03.013 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Hijacking of Cellular Ubiquitination Pathways by Lentiviruses and SAMHD1 Targeting by Vpx (A) Schematic representations of the lentiviral proteins Vif, Vpu, and Vpx (red)-mediated degradation of host restriction factors (green) by hijacking the cullin-RING E3 ubiquitin ligases. (B) Two distinct modes of recognition of SAMHD1 C-terminal tail (left) and N-terminal region (right) by Vpx and DCAF1 are shown as surface representations. Schematics of the interaction complex in the context of full-length SAMHD1 monomer are shown in the insets. Cell Host & Microbe 2015 17, 425-427DOI: (10.1016/j.chom.2015.03.013) Copyright © 2015 Elsevier Inc. Terms and Conditions