Diagnostic plots of the TGI PKPD model fitted to the A677 TGI data. Diagnostic plots of the TGI PKPD model fitted to the A677 TGI data. A, Prediction distribution plots: black dots represent observed TVs, lines represent median prediction of the model, and gray zones represent 95% confidence interval of the prediction. B, Observed versus predicted plots: dots represent observed TVs and lines represent identity line. Miro J. Eigenmann et al. Mol Cancer Ther 2016;15:3110-3119 ©2016 by American Association for Cancer Research