Reduction in craving expressed as area under the curve during 60 min for a) Nicorette 4 mg gum (♦), mouth spray (▴), lozenge (•) and placebo lozenge (▪); and b) Nicorette 4 mg gum (⋄), pouch (▵) and placebo pouch (□) [20]. Reduction in craving expressed as area under the curve during 60 min for a) Nicorette 4 mg gum (♦), mouth spray (▴), lozenge (•) and placebo lozenge (▪); and b) Nicorette 4 mg gum (⋄), pouch (▵) and placebo pouch (□) [20]. VAS: visual analogue scale. K. O. Fagerström, and C. A. Jiménez-Ruiz Eur Respir Rev 2008;17:192-198 ©2008 by European Respiratory Society