Expression analysis of IGFBP-3 using human whole-genome microarray. Expression analysis of IGFBP-3 using human whole-genome microarray. The average expression level of IGFBP-3 in metastatic melanoma patient samples (n = 30) was significantly higher (Wilcoxon test with two-tailed probability, P = 0.0005; 95% confidence interval for the median, 0.7592–2.5170) than primary melanoma patient samples (n = 14; 95% confidence interval for the median, 0.4005–0.9653). Yaguang Xi et al. Mol Cancer Ther 2006;5:3078-3084 ©2006 by American Association for Cancer Research