A proposed scheme for GSK-3-involved suppression of synaptic transmission. A proposed scheme for GSK-3-involved suppression of synaptic transmission. According.

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A proposed scheme for GSK-3-involved suppression of synaptic transmission. A proposed scheme for GSK-3-involved suppression of synaptic transmission. According the results observed in our study, we propose that activation of GSK-3 inhibits the expression and/or clustering of SynI, which in turn suppresses glutamate release and inhibits induction of LTP. The suppression of LTP then results in decreased synthesis of PSD proteins, and the decreased postsynaptic response inversely restricts the LTP. These impairments together may eventually lead to learning/memory deficits. Ling-Qiang Zhu et al. J. Neurosci. 2007;27:12211-12220 ©2007 by Society for Neuroscience