Correlations between leptin DNA methylation and 2-h post-OGTT glucose levels, within the IGT group (A and B), leptin DNA methylation and mRNA levels (C.

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Correlations between leptin DNA methylation and 2-h post-OGTT glucose levels, within the IGT group (A and B), leptin DNA methylation and mRNA levels (C and D); and leptin mRNA levels and circulating concentrations measured at the end of the third trimester (between weeks 36 and 37) of pregnancy (E and F). Correlations between leptin DNA methylation and 2-h post-OGTT glucose levels, within the IGT group (A and B), leptin DNA methylation and mRNA levels (C and D); and leptin mRNA levels and circulating concentrations measured at the end of the third trimester (between weeks 36 and 37) of pregnancy (E and F). IGT was defined as a 2-h glucose ≥7.8 mmol/l after a 75-g OGTT performed between 24 and 28 weeks of gestation. ‡Leptin DNA methylation n = 47 (NGT = 25 and IGT = 22). *Adjusted for first trimester BMI. †n = 43 (IGT [−] = 23 and IGT [+] = 20). AU, arbitrary units. Luigi Bouchard et al. Dia Care 2010;33:2436-2441 ©2010 by American Diabetes Association