Six-month change in proteinuria predicts risk for ESRD

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Six-month change in proteinuria predicts risk for ESRD Six-month change in proteinuria predicts risk for ESRD. Relationship between the risk for ESRD and initial change in proteinuria. Six-month change in proteinuria predicts risk for ESRD. Relationship between the risk for ESRD and initial change in proteinuria. The relative risk for ESRD during follow-up for different subgroups, defined by the change in the urine protein-to-creatinine ratio (UP:Cr) from baseline to 6 mo and controlling for randomized treatment group and the initial level of proteinuria, is shown. The reference group ranges from a 20% reduction in UP:Cr to a 25% increase. The cutoff values that define the change-in-proteinuria subgroups correspond to percentage changes that are symmetric on the log scale. Error bars represent SE. Reprinted from reference (4), with permission. George L. Bakris CJASN 2008;3:S3-S10 ©2008 by American Society of Nephrology