Correlation of RSPO expression to LGR5 expansion in gastric cancer.

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Correlation of RSPO expression to LGR5 expansion in gastric cancer. Correlation of RSPO expression to LGR5 expansion in gastric cancer. A and B, The Histoscore result for RSPO1 and 2 staining is not changed in tumor tissue (TU) compared with nonmalignant tissue (NT). Individual changes in the score result are shown below (n = 52). C and D, Total RSPO1 and 2 mRNA levels are significantly decreased in gastric cancer patients compared with their matched control tissue. Bar plot depicts the expression value difference for each case (n = 50). E–G, IHC staining of LGR5 (E), RSPO1 (F), and RSPO2 (G) on serial sections of an intestinal-type gastric cancer (×250 magnification). Brownish staining reveals concomitant expression of LGR5 and its ligands in close proximity. H and I, Splitting up the Histoscore result, the overall number of RSPO1/2+ cells significantly increases in gastric cancer patients (H). Nevertheless, intensity scores are negatively affected compared with nonmalignant tissue (I). K, Changes in the percentage of immunostained RSPO1 or 2 and LGR5 cells are correlated. Franziska Wilhelm et al. Mol Cancer Res 2017;15:776-785 ©2017 by American Association for Cancer Research