Estradiol and diet interact to regulate the number of newborn neurons that express ERα in the ARC and VMH of the adult female mouse. Estradiol and diet.

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Estradiol and diet interact to regulate the number of newborn neurons that express ERα in the ARC and VMH of the adult female mouse. Estradiol and diet interact to regulate the number of newborn neurons that express ERα in the ARC and VMH of the adult female mouse. A, B, Double-labeled BrdU- and ERα-expressing cells were seen through the rostral–caudal extent of the ARC (A) and VMH (B). There was an interaction between hormone and diet with an effect on the number of newborn ERα-expressing cells in the medial region of both areas. C, D, In the ARC (C) and VMH (D), a subpopulation of the newborn estrogen-sensitive (ERα) and leptin-sensitive (pSTAT3) neurons was identified. There was an interaction between hormone and diet with an effect on the number of these triple-labeled cells in the medial regions of both the ARC and VMH. Interaction between hormone and diet, p < 0.05; post hoc analysis revealed no significant differences between groups (see text for further explanation). Elizabeth P. Bless et al. eneuro 2016;3:ENEURO.0027-16.2016 ©2016 by Society for Neuroscience