Luc Van Kaer, Sebastian Joyce Immunity

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The Hunt for iNKT Cell Antigens: α-Galactosidase-Deficient Mice to the Rescue? Luc Van Kaer, Sebastian Joyce Immunity Volume 33, Issue 2, Pages 143-145 (August 2010) DOI: 10.1016/j.immuni.2010.08.009 Copyright © 2010 Elsevier Inc. Terms and Conditions

Figure 1 Proposed Role of the Lysosomal Enzyme α-Gal-A in the Biogenesis of Self-Antigens for iNKT Cells Based on the studies by Darmoise et al. (2010), a proposed mechanism for the autoreactivity of iNKT cells against wild-type DCs (left panel), DCs from Fabry mice (middle panel), and wild-type DCs stimulated with microbes or their products (right panel) is depicted. Red arrows denote signaling events, and the blue arrow denotes reduced enzymatic activity of α-Gal-A. LTP, lipid transfer protein; sPRR, signaling pattern-recognition receptor. Immunity 2010 33, 143-145DOI: (10.1016/j.immuni.2010.08.009) Copyright © 2010 Elsevier Inc. Terms and Conditions