FMRP S499 rephosphorylation kinetics after CX-4945 treatment and washout mirrors a known CK2 target. FMRP S499 rephosphorylation kinetics after CX-4945.

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FMRP S499 rephosphorylation kinetics after CX-4945 treatment and washout mirrors a known CK2 target. FMRP S499 rephosphorylation kinetics after CX-4945 treatment and washout mirrors a known CK2 target. A, N2a cells were collected either at baseline or 24 h after DMSO or CX-4945 treatment. Additional samples were collected after 24-h treatment and washout of DMSO or CX-4945 for different time periods. B, Quantification of [p/t]FMRP or [p/t]AKT compared with baseline. Changes in ratios were quantified by two-way ANOVA followed by Dunnett’s multiple comparisons post hoc test, n = 4 per data point, error bars = SEM. ****p < 0.0001; ***p < 0.001; *p < 0.05. Christopher M. Bartley et al. eNeuro 2016;3:ENEURO.0092-16.2016 ©2016 by Society for Neuroscience