Myocardium is a major source of proinflammatory cytokines in patients undergoing cardiopulmonary bypass Song Wan, MDa, Jean-Marie DeSmet, MDa, Luc Barvais,

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Presentation transcript:

Myocardium is a major source of proinflammatory cytokines in patients undergoing cardiopulmonary bypass Song Wan, MDa, Jean-Marie DeSmet, MDa, Luc Barvais, MDb, Marcelo Goldstein, MDc, Jean-Louis Vincent, MD, PhDc, Jean-Louis LeClerc, MDa The Journal of Thoracic and Cardiovascular Surgery Volume 112, Issue 3, Pages 806-811 (September 1996) DOI: 10.1016/S0022-5223(96)70068-5 Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 1 Plasma levels of TNF-α (A), IL-8 (B), IL-6 (C), and IL-10 (D) in peripheral artery (A), pulmonary artery (PA), and coronary sinus (CS) in one patient undergoing CABG who had postoperative myocardial infarction. BH, Before heparin administration; CC, 1 minute before aortic crossclamping; DC, 5 minutes after aortic declamping; 0.5h, 1h, 1.5h, 2h, time points after declamping. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 806-811DOI: (10.1016/S0022-5223(96)70068-5) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 1 Plasma levels of TNF-α (A), IL-8 (B), IL-6 (C), and IL-10 (D) in peripheral artery (A), pulmonary artery (PA), and coronary sinus (CS) in one patient undergoing CABG who had postoperative myocardial infarction. BH, Before heparin administration; CC, 1 minute before aortic crossclamping; DC, 5 minutes after aortic declamping; 0.5h, 1h, 1.5h, 2h, time points after declamping. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 806-811DOI: (10.1016/S0022-5223(96)70068-5) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 1 Plasma levels of TNF-α (A), IL-8 (B), IL-6 (C), and IL-10 (D) in peripheral artery (A), pulmonary artery (PA), and coronary sinus (CS) in one patient undergoing CABG who had postoperative myocardial infarction. BH, Before heparin administration; CC, 1 minute before aortic crossclamping; DC, 5 minutes after aortic declamping; 0.5h, 1h, 1.5h, 2h, time points after declamping. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 806-811DOI: (10.1016/S0022-5223(96)70068-5) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 1 Plasma levels of TNF-α (A), IL-8 (B), IL-6 (C), and IL-10 (D) in peripheral artery (A), pulmonary artery (PA), and coronary sinus (CS) in one patient undergoing CABG who had postoperative myocardial infarction. BH, Before heparin administration; CC, 1 minute before aortic crossclamping; DC, 5 minutes after aortic declamping; 0.5h, 1h, 1.5h, 2h, time points after declamping. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 806-811DOI: (10.1016/S0022-5223(96)70068-5) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 2 Plasma levels of TNF-α (A), IL-8 (B), IL-6 (C), and IL-10 (D) in peripheral artery (A), pulmonary artery (PA), and coronary sinus (CS) in nine patients undergoing uncomplicated CABG. Data are mean ± standard error of mean (error bars). Asterisk indicates p < 0.05; dagger indicates p < 0.01 versus arterial. BH, Before heparin administration; CC, 1 minute before aortic crossclamping; DC, 5 minutes after aortic declamping; 0.5h, 1h, 1.5h, 2h, time points after declamping. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 806-811DOI: (10.1016/S0022-5223(96)70068-5) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 2 Plasma levels of TNF-α (A), IL-8 (B), IL-6 (C), and IL-10 (D) in peripheral artery (A), pulmonary artery (PA), and coronary sinus (CS) in nine patients undergoing uncomplicated CABG. Data are mean ± standard error of mean (error bars). Asterisk indicates p < 0.05; dagger indicates p < 0.01 versus arterial. BH, Before heparin administration; CC, 1 minute before aortic crossclamping; DC, 5 minutes after aortic declamping; 0.5h, 1h, 1.5h, 2h, time points after declamping. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 806-811DOI: (10.1016/S0022-5223(96)70068-5) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 2 Plasma levels of TNF-α (A), IL-8 (B), IL-6 (C), and IL-10 (D) in peripheral artery (A), pulmonary artery (PA), and coronary sinus (CS) in nine patients undergoing uncomplicated CABG. Data are mean ± standard error of mean (error bars). Asterisk indicates p < 0.05; dagger indicates p < 0.01 versus arterial. BH, Before heparin administration; CC, 1 minute before aortic crossclamping; DC, 5 minutes after aortic declamping; 0.5h, 1h, 1.5h, 2h, time points after declamping. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 806-811DOI: (10.1016/S0022-5223(96)70068-5) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 2 Plasma levels of TNF-α (A), IL-8 (B), IL-6 (C), and IL-10 (D) in peripheral artery (A), pulmonary artery (PA), and coronary sinus (CS) in nine patients undergoing uncomplicated CABG. Data are mean ± standard error of mean (error bars). Asterisk indicates p < 0.05; dagger indicates p < 0.01 versus arterial. BH, Before heparin administration; CC, 1 minute before aortic crossclamping; DC, 5 minutes after aortic declamping; 0.5h, 1h, 1.5h, 2h, time points after declamping. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 806-811DOI: (10.1016/S0022-5223(96)70068-5) Copyright © 1996 Mosby, Inc. Terms and Conditions