IL‐7‐dependent compositional changes within the γδ T cell pool in lymph nodes during ageing lead to an unbalanced anti‐tumour response The diversity of.

Slides:

Advertisements

Similar presentations

Individualized pain management plan.

Advertisements

Isotope‐based Fluvial Organic Carbon (ISOFLOC) Model: Model formulation, sensitivity, and evaluation Reach‐scale conceptual model of the fluvial carbon.

Isotope‐based Fluvial Organic Carbon (ISOFLOC) Model: Model formulation, sensitivity, and evaluation Modeling domain for the main stem of the South Elkhorn.

(a) illuminance measured in the horizontal plane from a typical street light (Phillips Cosmopolis, metal halide lamp). The intensity of light decays rapidly.

Isotope‐based Fluvial Organic Carbon (ISOFLOC) Model: Model formulation, sensitivity, and evaluation Sensitivity analysis of the ISOFLOC model displays.

Isotope‐based Fluvial Organic Carbon (ISOFLOC) Model: Model formulation, sensitivity, and evaluation Model flowchart for ISOFLOC which details inputs,

Evening evapotranspirative cooling in relation to vegetation and urban geometry in the city of Ouagadougou, Burkina Faso Relation between sky view factor.

KLF4 is a key determinant in the development and progression of cerebral cavernous malformations qRT–PCR analysis of Klf4 during disease progression at.

Defective immune responses in mice lacking LUBAC‐mediated linear ubiquitination in B cells Cpdm mice show residual LUBAC‐mediated linear polyubiquitination.

Shifting meiotic to mitotic spindle assembly in oocytes disrupts chromosome alignment Spinning disk confocal microscopy images showing spindle region magnifications.

Details of the binding sites of tetracycline and edeine

The mitochondrial outer membrane protein MDI promotes local protein synthesis and mtDNA replication Representative images of wt and mdi1 ovarioles stained.

Co‐immunoprecipitation of Larp with MDI‐myc in transfected S2 cells

Allelic exchange at the endogenous genomic locus in Plasmodium falciparum proves the role of dihydropteroate synthase in sulfadoxine‐resistant malaria.

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries Global Maps Presenting the Most.

SORCS1 and SORCS3 control energy balance and orexigenic peptide production Representative hematoxylin and eosin (H&E)‐stained sections of perigonadal white.

Exogenous N‐acyl‐homoserine lactones enhance the expression of flagella of Pseudomonas syringae and activate defence responses in plants Comparisons of.

SORCS1 and SORCS3 control energy balance and orexigenic peptide production A, BBlood glucose (A) and insulin (B) levels after overnight fasting in 9‐month‐old.

Regional weather and climates of the British Isles ‐ Part 1: Introduction The annual rainfall anomaly (percentage difference from normal) for Western Scotland.

A dynamical model of the spindle position checkpoint

Applications of genome‐scale metabolic reconstructions

Representative electron density maps

Endosome and Golgi‐associated degradation (EGAD) of membrane proteins regulates sphingolipid metabolism Equal amounts of WT cells and indicated single.

Retinoids activate proton transport by the uncoupling proteins UCP1 and UCP2 (A) pH dependency of the state 4 respiratory rate: control ▵ and UCP2 mitochondria.

Anthropogenic noise weakens territorial response to intruder's songs

Checkpoint kinase 1 is essential for fetal and adult hematopoiesis

Retinoids activate proton transport by the uncoupling proteins UCP1 and UCP2 (A) Effect of palmitic acid on the respiratory rate of mitochondria isolated.

Prevalence of women with advanced maternal age by country.

Model for end‐stage liver disease exception points for treatment‐responsive hepatocellular carcinoma Treatment‐responsive HCC: patient with complete response.

Tousled‐like kinase 2 regulates recovery from a DNA damage‐induced G2 arrest U2OS cells were transfected with four independent siRNAs from the pools used.

Taurine as a constituent of mitochondrial tRNAs: new insights into the functions of taurine and human mitochondrial diseases Schematic depiction of modification.

Small interfering RNAs based on huntingtin trinucleotide repeats are highly toxic to cancer cells Ten nucleotide Sylamer analysis of the ORFs of genes.

Sequential treatment with 5‐aza‐2′‐deoxycytidine and deacetylase inhibitors reactivates HIV‐1 One night after cell purification, CD8+‐depleted PBMCs from.

Sequential treatment with 5‐aza‐2′‐deoxycytidine and deacetylase inhibitors reactivates HIV‐1 One night after cell purification, HLA DR− CD69− CD25− CD4+

Induced chromosome deletions cause hypersociability and other features of Williams–Beuren syndrome in mice Expression of genes measured by real‐time qRT‐PCR.

Structural and functional analysis of the GABARAP interaction motif (GIM) Interaction profile of 30 biotinylated LIR peptides from various proteins against.

DAP‐kinase is a Ca2+/calmodulin‐dependent, cytoskeletal‐associated protein kinase, with cell death‐inducing functions that depend on its catalytic activity.

Small interfering RNAs based on huntingtin trinucleotide repeats are highly toxic to cancer cells Confluence over time of HeyA8 (top) or A549 (bottom)

Mammary stem cells and progenitors: targeting the roots of breast cancer for prevention (A) Schematic of the human breast highlighting terminal ductal.

Mapping the interaction of Snf1 with TORC1 in Saccharomyces cerevisiae

Comparison of protein synthesis rate of endogenous E

SORCS1 and SORCS3 control energy balance and orexigenic peptide production A, BTranscript levels for Sorcs1 (A) and Sorcs3 (B) in the indicated mouse tissues.

Structural and functional analysis of the GABARAP interaction motif (GIM) GFP‐mCherry‐p62/SQSTM1 WT, T339V, L341V and T339V/L341V were overexpressed in.

Involvement of Crm1 in the hemin‐induced nuclear exclusion of Bach1

Kinesin‐2 motors adapt their stepping behavior for processive transport on axonemes and microtubules A–CThe movement of single KLP3A/B motors fluorescently.

The trimeric coiled‐coil HSBP1 protein promotes WASH complex assembly at centrosomes MDA‐MB‐231 clones stably transfected with plasmids expressing control.

Extensive quantitative remodeling of the proteome between normal colon tissue and adenocarcinoma Abundance of proteins matching selected subcellular locations.

GSTZ1‐1 Deficiency Activates NRF2/IGF1R Axis in HCC via Accumulation of Oncometabolite Succinylacetone AGSTZ1 mRNA expression in HCC and paired non‐tumor.

D‐Aspartate treatment attenuates myelin damage and stimulates myelin repair ALeft: Superimposed single‐cell traces representative of the effect of 10 μM.

Heterogeneity in Δψmit reported by TMRE

Mitochondria are morphologically and functionally heterogeneous within cells Surface‐rendered three‐dimensional reconstructions of cells expressing mito‐DsRed1.

Malaria inflammation by xanthine oxidase‐produced reactive oxygen species A, BMacrophages produce little to no inflammatory cytokines when incubated with.

Dual melanocortin‐4 receptor and GLP‐1 receptor agonism amplifies metabolic benefits in diet‐induced obese mice A–DCholesterol metabolic parameters were.

Cesarean section scar diverticulum evaluation by saline contrast‐enhanced magnetic resonance imaging: The relationship between variable parameters and.

Checkpoint kinase 1 is essential for fetal and adult hematopoiesis

The p97/VCP ATPase is critical in muscle atrophy and the accelerated degradation of muscle proteins The content of p97 and two of its cofactors are induced.

The p97/VCP ATPase is critical in muscle atrophy and the accelerated degradation of muscle proteins Electroporation of DNp97 in TA blocks both denervation.

Cell‐specific responses to the cytokine TGFβ are determined by variability in protein levels Unimodal distribution of protein concentrations in artificial.

Shifting meiotic to mitotic spindle assembly in oocytes disrupts chromosome alignment ASpinning disk confocal microscopy images showing spindle region.

M‐LDH serves as a sarcolemmal KATP channel subunit essential for cell protection against ischemia The opening of KATP channels and intact activity of M‐LDH.

Repeat‐associated non‐AUG translation in C9orf72‐ALS/FTD is driven by neuronal excitation and stress AFilter‐trap binding assays show that the ISR proteins.

STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cells IL‐3‐induced apoptosis in Ba/F3 cells expressing.

CNOT6L couples the selective degradation of maternal transcripts to meiotic cell cycle progression in mouse oocyte Relative mRNA copy number dynamics in.

The Escherichia coli RNA polymerase α subunit linker: length requirements for transcription activation at CRP‐dependent promoters Comparison of the effect.

Imaging Disaster: Puerto Rico through the Eye of Hurricane María

CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression Immunoprecipitation of CD147 from RBL.

CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression The transmembrane and cytoplasmic regions.

Lysine acetylome profiling uncovers novel histone deacetylase substrate proteins in Arabidopsis RuBisCO initial and total activity in WT and hda14 in low‐light‐treated.

Myeloid leukemia with transdifferentiation plasticity developing from T‐cell progenitors Representative FACS plot (left) showing a mixed‐lineage clone.

Range expansion and distributional limits of the nine‐banded armadillo in the United States: an update of Taulman & Robbins () Estimated boundary of the.

Presentation transcript:

IL‐7‐dependent compositional changes within the γδ T cell pool in lymph nodes during ageing lead to an unbalanced anti‐tumour response The diversity of TCRγ (top) and TCRδ (bottom) repertoires was evaluated in sorted Vγ1+ γδ1, Vγ4+ γδ1 and Vγ4+ γδ17 subsets of young and old mice and is represented as inverse Simpsons index. Vδ chain usage in Vγ1+ γδ1, Vγ4+ γδ1 and Vγ4+ γδ17 and Vγ6+ γδ17 T‐cell subsets from young and old mice (§TRDV3 is a pseudogene). The fraction of in‐frame rearrangements of Vδ gene segments within the sorted populations is shown. Emerging and declining clones defined by CDR3 nucleotide sequence in old mice. Heat map and indicated frequency show the abundance of specific clones in each young and old individual. (Inset right) Percentage of the canonical CDR3 amino acid sequence CASGYIGGIRATDKLVF in sorted Vγ4+ γδ17 T cells from the pLNs of young and old mice. IMGT gene names and their corresponding TCR Vδ chains are summarised in Appendix Table S2. Data information: Data shown are from 4 to 6 mice/condition (three independent experiments). Statistical significances for changes were assessed by Mann–Whitney test (A and C) or two‐way ANOVA (B). In the box plots (A–C), lower and upper hinges indicate the first and third quartile, and the horizontal line within the box indicates the median. Upper whiskers extend from Q3 to 1.5× IQR (inter quartile range) and lower whiskers from Q1 to 1.5× IQR. Outliers identified by Tukey's rule were plotted individually (A and B). **P < 0.01; ***P < 0.001; ****P < 0.0001. IF THIS IMAGE HAS BEEN PROVIDED BY OR IS OWNED BY A THIRD PARTY, AS INDICATED IN THE CAPTION LINE, THEN FURTHER PERMISSION MAY BE NEEDED BEFORE ANY FURTHER USE. PLEASE CONTACT WILEY'S PERMISSIONS DEPARTMENT ON PERMISSIONS@WILEY.COM OR USE THE RIGHTSLINK SERVICE BY CLICKING ON THE 'REQUEST PERMISSIONS' LINK ACCOMPANYING THIS ARTICLE. WILEY OR AUTHOR OWNED IMAGES MAY BE USED FOR NON-COMMERCIAL PURPOSES, SUBJECT TO PROPER CITATION OF THE ARTICLE, AUTHOR, AND PUBLISHER. EMBO Rep, Volume: 20, Issue: 8, First published: 08 July 2019, DOI: (10.15252/embr.201847379)