In Search of the Ever-Elusive Positive Endozepine

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In Search of the Ever-Elusive Positive Endozepine Stephen C. Harward, James O. McNamara Neuron Volume 78, Issue 6, Pages 951-952 (June 2013) DOI: 10.1016/j.neuron.2013.06.004 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 Dbi Gene Products Can Bind to the BR of GABAARs and Positively or Negatively Modulate GABA-Mediated Function Following the work of Christian et al. (2013), there is now evidence that the various products arising from the Dbi gene can bind to the BR of GABAARs and act as both PAMs and NAMs in the CNS. The specific function (either positive or negative) appears to be brain region specific. Understanding how these opposing effects arise from the same gene will shed light on GABAAR function in health and disease. Neuron 2013 78, 951-952DOI: (10.1016/j.neuron.2013.06.004) Copyright © 2013 Elsevier Inc. Terms and Conditions