Effects the genotypes of Rapgef2 and Rapgef6 on RG fiber organization and neuronal migration. Effects the genotypes of Rapgef2 and Rapgef6 on RG fiber.

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Effects the genotypes of Rapgef2 and Rapgef6 on RG fiber organization and neuronal migration. Effects the genotypes of Rapgef2 and Rapgef6 on RG fiber organization and neuronal migration. A, Morphology of RG fibers. Coronal sections of the brains of Rapgef2-f/f (2-f/f), Rapgef2-cKO (2-cKO), Rapgef6-KO (6-KO), and Rapgef2/6-dKO (2/6-dKO) embryos at E13.5 and E15.5 were subjected to immunostaining for nestin. The images are representative of three biological replicates of each group. Scale bars, 50 µm. B, Morphology of ectopically located GFP-labeled cells. RGCs lining the apical surface of the 2-f/f and 2-cKO cortices were labeled with GFP by IUE of pCAG-EGFP-F at E14.5, and the morphology of their progenies was analyzed at E15.5 by immunohistological staining for GFP (green) and Pax6 (red). GFP+/Pax6+ RGCs are indicated by arrowheads. The apical and pial surfaces of the telencephalon were indicated by white broken lines. The images are representative of four biological replicates of each group. Scale bars: 20 µm C, Localization of Ctip2+ neurons. Coronal sections of the brains of the E13.5 and E15.5 embryos with the indicated genotypes were subjected to immunostaining for Ctip2 (red) and DAPI (blue). The images are representative of three biological replicates of each group. Scale bars, 50 µm. Kazuhiro Maeta et al. eneuro 2016;3:ENEURO.0142-16.2016 ©2016 by Society for Neuroscience