The incidence of apoptosis is increased in the Ts16 cortical wall.

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The incidence of apoptosis is increased in the Ts16 cortical wall. The incidence of apoptosis is increased in the Ts16 cortical wall. A, The number of apoptotic cells within the cortical wall from E15 to E18 was increased in Ts16 brains (open bars) as compared with controls (solid bars). B, Dying cells at E16 were found throughout the cortical wall in Ts16 brains, most dramatically within the proliferative ventricular zone (VZ). In contrast, most apoptotic cells within euploid cortices were located in the intermediate zone (IZ) and cortical plate (CP), which contain postmitotic neurons. Mean ± SEM (n = 6 pairs at each age); *p < 0.05; **p < 0.005. Tarik F. Haydar et al. J. Neurosci. 2000;20:4156-4164 ©2000 by Society for Neuroscience