Brief Discussions Genetics Beta-Cell Immune Modulation/Inflammation

Slides:

Advertisements

Similar presentations

بسم الله الرحمن الرحيم. Immunological markers in the pathogenesis of type 1 diabetes in Saudi children.

Advertisements

Immune control of human papillomavirus (HPV) associated anogenital disease and potential for vaccination Peter L. Stern Journal of Clinical Virology, 2005.

تحلیل اصطلاحات پزشکی پاراگراف بیماریزایی دیابت قندی نوع 1 امید طرازی زاده یزدی.

Concepts in the natural history of diabetes.

Biotechnology pp WHAT IS IT?  Biotechnology : the application of technology to better use DNA and biology.

生物主題報告 Insulin and diabetis

Type 1 Diabetes Treatment Options Stanley Schwartz Mark Stolar Emeritus, Univ of Pa Part 1.

Practical Implementation as a Discussion with the Patient Practical Use of SGLT-2 Inhibitors in T2DM: Clinical Pearls- Perlas de Sabiduria Stan Schwartz.

Diagnosing Diabetes In Adults– Type 1, LADA, or Type 2? Stanley Schwartz MD, FACE, FACP Affiliate Main Line Health Emeritus, Clinical Assoc. Prof. of Medicine.

IR and Hyperinsulinemia Insulin Resistance: A Survival Mechanism, Gone Awry Stan Schwartz MD,FACP Affiliate, Main Line Health System Emeritus, Clinical.

Diagnosing Diabetes In Adults– Type 1, LADA, or Type 2? Stanley Schwartz MD, FACE, FACP Affiliate Main Line Health Emeritus, Clinical Assoc. Prof. of Medicine.

Type 1 diabetes is an auto-immune disease in which the body's immune system destroys the insulin-producing beta cells in the pancreas. It is triggered.

Genetic DNA Vaccines By Chelsea Heimbrock. What are DNA Vaccines? An injection of genes of a virus into the body that creates an immune response for the.

Type I Diabetes Juvenile diabetes – develops early in life Beta cells in pancreas do not produce insulin Genetic predisposition – virus may trigger an.

Interleukin-1-Receptor Antagonist in Type 2 Diabetes Mellitus Claus M. Larsen, M.D., Mirjam Faulenbach, M.D., Allan Vaag, M.D., Ph.D., Aage Vølund, M.Sc.,

Brief Discussions Genetics Beta-Cell Immune Modulation/Inflammation Insulin Resistance Environment.

Current Classification of DM Update on Diabetes Classification Celeste C. Thomas, MD, MSa,*, Louis H. Philipson, MD, PhD,Med Clin N Am 99 (2015) 1–16.

Pathogenesis and biological interventions in T1DM- LIKE autoimmune diabetes- Insulitis The class I MHC molecules are hyperexpressed on the β-cell surface.

Glucose Metabolism Dr Lenon T Gwaunza MBChB, BSc (Hons), MSc (UCL)

Stages of Neoplastic Transformation. Activation BAD Carcinogen: contributes to causing cancer; creates free radicals Carcinogen: contributes to causing.

Diabetes in the Pediatric Population

Efficacy of Immunotherapy in T1DM: Some Can Delay Decline in C-peptide

CV Risk of SU and Insulin

LINKS BETWEEN DRUG METABOLISM AND

The β-Cell Centric Classification of DM

β-Cell Centric Classification of Diabetes:

A Process Of Precision Medicine- Matching Right Drug to Right Patient

NATURAL HISTORY OF BETA CELL FAILURE IN T2DM

Beta-Cell Classification of Diabetes and the Egregious Eleven: Logic for Newer Algorithms/ Processes of Care The Role of Newer Anti-Diabetes Medications.

Most Mechanisms of B-Cell Damage (Hyperglycemia) Overlap with Causes of Vascular Disease : Provides Logic for Treatment Regimes and CV Benefits.

In T2DM, β-Cell Mass in Islets is Significantly Reduced

New β-Cell Centric Construct: Implications Genetics 101 for DM

Pathophysiology of Type 1 Diabetes

A Clinical-Translator’s Point-of-View:

PLASMIDS ...and genetic engineering..

Unified Theory of Diabetes and All Its Complications

Targets for Therapies/ New Guidelines

Diabetes Mellitus.

Pushback What about ‘pure’ Insulin Resistance Syndromes?

CV Risk of SU and Insulin

Chromosomes, Genes & DNA.

209. Use of Helicobacter pyroli Neutrophil Activating Protein (NAP) as an Immune- Modulatory Agent To Enhance the Efficacy of Oncolytic Adenovirus Therapy.

Protein Synthesis.

Genetics Definitions Definition Key Word

Value of construct 1. Fits with Harry Keen’s construct

Inflammation/Immune Issues

Genetics and epigenetics of NAFLD and NASH

Nat. Rev. Endocrinol. doi: /nrendo

The β-Cell Centric Classification of DM

Simplistic Inflammatory and Non-Inflammatory Effects of Insulin Resistance on B-Cell Function IAPP boosts islet macrophage IL-1 in type 2 diabetes : Nature.

Beta-Cell Classification of Diabetes and the Egregious Eleven: Logic for Newer Algorithms/ Processes of Care The Role of Newer Anti-Diabetes Medications.

Colorectal cancer : Three pathways

627. Non-Invasive, Multimodal Imaging of Microvesicles with Metabolically Biotinylated, Membrane-Bound Gaussia Luciferase Molecular Therapy Volume.

WHAT ABOUT COMPLICATIONS OF DIABETES?

162. Stability of Polymer/Plasmid DNA Complexes In Vitro and In Vivo

Chapter 12: Heredity Advances in Genetics.

Volume 15, Issue 1, Pages (January 2007)

Cancer Cells Packet # 17 Thursday, January 17, 2019.

The Stunned β Cell: A Brief History

An Integrated View of Immunometabolism

Estrogen Receptor Transrepresses Brain Inflammation

Non coding DNA Coding Not all DNA codes for a polypeptide to be made May have another useful function Non-coding sequences of DNA e.g. STRs Another example:

847. Eradication of Therapy-Resistant Human Prostate Tumors Using an Ultrasound Guided Site-Specific Cancer Terminator Virus Delivery Approach Molecular.

Jin Zhang, Hu Li, Alan Trounson, Joseph C. Wu, Paul Nioi

674. Molecular, Biochemical and Biomechanical Analysis of Articular Cartilage Repaired with Genetically Modified Chondrocytes Expressing Insulin-Like.

Glucose transporter (GLUT1) allele (XbaI–) associated with nephropathy in non-insulin- dependent diabetes mellitus Zhi-Hong Liu, Tian-Jun Guan, Zhao-Hong.

86. A Highly Compact Epitope-Based Marker Suicide Gene for Safer and Easier Adoptive T-Cell Gene Therapy Molecular Therapy Volume 20, Pages S35-S36.

Nature of Biology 1 Chapter 15 pg

Fig. 4. Effects of natriuretic peptide receptor 2 (NPR2) knockdown on cells apoptosis in mouse Leydig cells. (A) Relative mRNA expression of cell apoptosis.

Cancer Cells Packet # 6.

Presentation transcript:

Brief Discussions Genetics Beta-Cell Immune Modulation/Inflammation Insulin Resistance Environment

New β-Cell Centric Construct: Implications Genetics 101 for DM Phenotype is DEPENDENT ON Genotype: Number of Genes- which genes- their nature, how many different ones, the ‘severity/intensity’ of expression!; epigenetics i.e: Genes influence: B-Cell: Insulin secretory dynamics, sites of susceptibility of β-Cell to destruction by endogenous/ exogenous triggers Immune Modulation/Inflammation Insulin Resistance Environment (AND some address susceptibility to DM comp. Understanding type 2 diabetes: from genetics to epigenetics. Raciti GA, Longo M, Parrillo L, Ciccarelli M, Mirra P, Ungaro P, Formisano P, Miele C, Béguinot F. Acta Diabetol. 2015 Apr 5. *Int J Biochem Cell Biol. 2015 May 27. pii: S1357-2725(15)00143-0. doi: 10.1016/j.biocel.2015.05.022. [Epub ahead of print] Epigenetic dynamics in immunity and autoimmunity. Zhao M1, Wang Z1, Yung S2, Lu Q. ;

Bakay M, Pandey R, Hakonarson H. Genes Involved in Type 1 Diabetes Bakay M, Pandey R, Hakonarson H. Genes Involved in Type 1 Diabetes. In InTech, Type 1 Diabetes, Chap 3. 2013. Escher AP and Li A, editors. http://dx.doi.org/10.5772/52435

Bakay M, Pandey R, Hakonarson H. Genes Involved in Type 1 Diabetes Bakay M, Pandey R, Hakonarson H. Genes Involved in Type 1 Diabetes. In InTech, Type 1 Diabetes, Chap 3. 2013. Escher AP and Li A, editors. http://dx.doi.org/10.5772/52435

New β-Cell Centric Construct: Implications β-cell Issues Usual use of Glycemic Criteria- HgA1c, FBS, PPG Markers-Usual/Classic= C-Peptide New Non-Invasive β-Cell Mass Measures- Nano-particle labeled exendin imaging Circulating DNA Markers of β-Cell Destruction Glazer- Hebrew Univ Circulating mRNAs NO LOGIC FOR USE OF AGENTS THAT MAY CONTRIBUTE TO APOPTOSIS of β-Cell STOP USING SU’s, GLINIDES; Minimize INSULIN THERAPY