Fig. 3. Occludin and ZO-1 decrease in hippocampus of aged SHRs. A Fig. 3. Occludin and ZO-1 decrease in hippocampus of aged SHRs.A. Occludin (red) and GFAP (green) immunoreactivity in hippocampus of age-matched WKY rats (upper row) and aged SHRs (lower row). B. ZO-1 (red) and GFAP (green) immunoreactivity in hippocampus of age-matched WKY rats (upper row) and aged SHRs (lower row). White asterisks indicate BBB surrounded by astrocyte processes. White arrows refer to decrease of occludin or ZO-1. Bar = 50 μm. GFAP = glial fibrillary acidic protein, ZO-1 = zonula occludens-1 Fig. 3. Occludin and ZO-1 decrease in hippocampus of aged SHRs.A. Occludin (red) and GFAP (green) immunoreactivity in hippocampus of age-matched WKY rats (upper row) and aged SHRs (lower row). B. ZO-1 (red) and GFAP (green) immunoreactivity in hippocampus of age-matched WKY rats (upper row) and aged SHRs (lower row). White asterisks indicate BBB surrounded by astrocyte processes. White arrows refer to decrease of occludin or ZO-1. Bar = 50 μm. GFAP = glial fibrillary acidic protein,… Korean J Radiol. 2018 May-Jun;19(3):498-507. https://doi.org/10.3348/kjr.2018.19.3.498